As a result, transplantation of exogenous stem cells into the injured heart to enhance cardiogenesis has been investigated as a therapeutic approach for heart regeneration. Currently, two major types of stem cells are being investigated: multipotent stem cells (adult stem cells) and pluripotent stem ...
The potential sources of the tissues to regenerate organs include cloned cells, embryonic or fetal stem cells, or adult stem cells. Although each of these sources of stem cells has potential biological advantages and disadvantages, ethical and legal concerns have been raised by cloning (1鈥 4) ...
Although each of these sources of stem cells has potential biological advantages and disadvantages, ethical and legal concerns have been raised by cloning (1–4) and the use of embryonic and fetal stem cells (5) . 展开 关键词:stem cells bone marrow regeneration and repair ...
A notable exception to the tissue specificity of adult stem cells is theMSC, also known as the multipotent adultprogenitor cell. This cell type is derived from bone marrow stroma.80,81Such cells can differentiatein vitrointo numeroustissue types82,83and can also differentiate developmentally if inj...
Stem cell therapies have been widely investigated for their healing effects. However, the translation of these therapies has been hampered by the requirement to deliver live allogeneic or autologous cells directly to the wound in a clinical setting. Mult
Current therapeutic strategies for type I diabetes focus on three major directions, with distinct advantages and disadvantages: arrest of autoimmunity, islet transplantation and generation of neoislets. There is mounting evidence that candidate stem cells residing in the hematopoietic compartments participate...
and cancer. The differentiation of stem cells from autologous amniotic fluid iPS cells into functional cardiomyocytes has been demonstrated. Further work with the scale up and preconditioning of these cardiomyocytes could circumvent the scarcity of heart donors in infants with several heart failure. Altho...
The outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for adult T-cell leukemia/lymphoma (ATL) is still unsatisfactory. To illustrate the advantages and disadvantages of each donor source, we performed a nationwide retrospective study of graft-versus-host disease (GVHD)-free,...
ATL cells from hypercalcemic ATL patients express RANK ligand, and induced the differentiation of hematopoietic stem cells into osteoclasts when ATL cells were co-cultured with hematopoietic stem cells [111]. In addition, the serum level of parathyroid hormone-related peptide (PTH-rP) is also ...
Briefly, in the first step, acquisition of all cells present in the sample was performed and at this point at least 20 000 events per tube were measured. Subsequently, in a second step, a multiparametric live gate was used to acquire more data specifically on leukemic cells potentially ...