Rob Stein
Therefore, this systematic review aims to provide a comprehensive overview of advances in the discovery and development of drugs targeting the KKS. Besides the approved drugs, it will focus on promising new drug candidates, their mode of action, new indications and their potential for approval in ...
The diagnosis of sickle cell nephropathy is made by detecting abnormalities such as albuminuria, hematuria or CKD rather than by distinct diagnostic criteria in SCD, which have not been developed. Traditional markers of kidney function such as serum creatinine and eGFR should be interpreted with cauti...
Furthermore, the release of multiple molecules, including damage-associated molecular patterns (DAMPs), following cell death by ferroptosis, is examined, as these molecules further influence the differentiation and function of immune cells, thereby affecting the occurrence and progression of autoimmune dise...
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The basic idea of modulating the immune system to better recognize and fight tumor cells has led to the successful introduction of adoptive cellular immunotherapy (ACT). ACT-based treatment regimens, in which the patient's own immune cells are isolated a
in the field of regenerative medicine and cell therapy [8,11,13,14]. MSCs can be directly administered to the injured area in vivo, or a novel cell-free approach utilizing extracellular vesicles (EVs) can replace live stem cells. Because the therapeutic effect of MSCs primarily relies on ...
Although the gut microbiota is too numerous to characterize, a few analytical tools are available to aid in the study of specific organisms of interest to disease. Metagenomic analysis is one of the powerful tools currently used to reconstruct microbial species and their function by examining genetic...
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug — the monoclonal
There is some evidence of inflamed airway in children with atopic eczema who do not suffer from asthma [7]. It may be possible that the detection of inflammatory markers may be useful for identifying who are at risk of asthma exacerbation. Controllers, mainly inhaled corticosteroids, are used ...