The diagnosis of sickle cell nephropathy is made by detecting abnormalities such as albuminuria, hematuria or CKD rather than by distinct diagnostic criteria in SCD, which have not been developed. Traditional markers of kidney function such as serum creatinine and eGFR should be interpreted with cauti...
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In rec...
The basic idea of modulating the immune system to better recognize and fight tumor cells has led to the successful introduction of adoptive cellular immunotherapy (ACT). ACT-based treatment regimens, in which the patient's own immune cells are isolated and subsequently expanded (ex vivo) and rei...
12]. Due to their multipotency and robust proangiogenic, proepithelial, neurotrophic, antifibrotic, antiapoptotic, and immunomodulatory effects demonstrated in numerous in vitro and in vivo studies, ADSCs have been extensively utilized in the field of regenerative medicine and cell therapy [8,11,13,1...
In the CAPRIE trial, an 8.7% relative risk reduction in vascular death, ischaemic stroke or myocardial infarction was found with clopidogrel versus aspirin. Subset analyses of the CAPRIE study have demonstrated that the benefits of clopidogrel over aspirin are amplified in high-risk patients. ...
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There is some evidence of inflamed airway in children with atopic eczema who do not suffer from asthma [7]. It may be possible that the detection of inflammatory markers may be useful for identifying who are at risk of asthma exacerbation. Controllers, mainly inhaled corticosteroids, are used ...
in the field of regenerative medicine and cell therapy [8,11,13,14]. MSCs can be directly administered to the injured area in vivo, or a novel cell-free approach utilizing extracellular vesicles (EVs) can replace live stem cells. Because the therapeutic effect of MSCs primarily relies on ...
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body
Despite making up only 3% of the analyzed samples (57/1929), 14.7% of the variants were present only in sampled wolves, while 15.2% of total sites are absent from wolves. This may be a reflection of the small number of wolves in the study. A total of 11.8% of the variants are ...