hypercalcemia,and hyperviscosity syndrome.The recent discovery of biomarkers related to the diagnosis or prognosis of MM provides an important basis for the diagnosis and treatment of MM.This paper reviews the research progress of biomarkers expressed in tissues and peripheral blood at home and abroad...
During the separation and extraction process, subtypes of ApoEVs cannot be clearly distinguished [28]. Except for size, there are no other standardized and executable criteria to distinguish among various ApoEVs [39]. In some experiments, the vesicles utilized do not match the corresponding sizes....
Biomarkers for the Diagnosis of Renal Allograft and Kidney Status The present invention relates to the identification and use of protein biomarkers with clinical relevance to kidney status and chronic renal injury or disorder. In particular, the invention provides the identity of marker proteins which ...
There have been major advances in the diagnosis, staging, risk-stratification, and management of multiple myeloma (MM). In addition to established CRAB (hypercalcemia, renal failure, anemia, and lytic bone lesions) features, new diagnostic criteria include three new biomarkers to diagnose the disease...
Cell-free DNA levels in plasma of patients with non-small-cell lung cancer and inflammatory lung disease. The analysis of plasma cell-free DNA (cfDNA) is expected to provide useful biomarkers for early diagnosis of non-small-cell lung cancer (NSCLC). However, i... A,Szpechcinski,J,......
Exosomes are a type of extracellular vesicle actively secreted by almost all eukaryotic cells. They are ideal candidates for reliable next-generation biomarkers in the early diagnosis and therapeutic response evaluation of cancer. Thus, the quantification of exosomes is crucial in facilitating clinical re...
Several obstacles have to be overcome, however, to reach testing efficiencies good enough for solid tumours, explains Hu. “The biggest challenge for detecting solid tumour MRD is that the amount of ctDNA in the blood is so low, and there are so many potential biomarkers to read in order ...
Additionally, precision nanomedicine could enhance safety, by providing individualized nano-platforms tailored to different patient subgroups based on biomarkers or clinical manifestations. Apart from cancer treatment, nanotechnology could revolutionize medical imaging techniques. The imaging of NPs and their ...
in the development of the germinal center and the response to antigens; thus, it is known as a germinal center marker [125]. It has been reported that BCL-6 can inhibit the expression of PRDM1, which is an important regulatory gene for plasma cell differentiation [126]. In addition, ...
Exploring alternative immune effector cells, such as CAR-NK cells and TCR-engineered T cells, presents further avenues for effective treatment. Establishing robust biomarkers for patient selection and response monitoring is vital for personalizing treatment strategies. ...