In patients with chronic kidney disease (CKD), disorders of mineral metabolism are associated with vascular calcifications and mortality. Microvascular dysfunction, by affecting flow resistance and tissue perfusion, may explain the cardiovascular sequelae of CKD-associated disorders of mineral metabolism. ...
The sex-dependent changes in placental glucocorticoid handing induced by advanced maternal age may also explain offspring outcomes. Work in small and large animal models has demonstrated that elevated prenatal exposure to glucocorticoids affects fetal development and permanently alters organ structure and fun...
Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Nasal allergies, chronic or Nasal polyps or Rhinitis (runny nose), chronic or Sinusitis, chronic—Use is not recommended due to potential for nasal irritation. ...
Oxidative Stress in Age-Related Chronic Disease: From Bench to Bedside Sections PDF Tools Share Abstract Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxyge...
“graveyard for dead thymocytes”23. Furthermore, the thymus undergoes an age-associated involution process with important structural and cellular changes in cortex and medulla, the mechanisms and cause of which are yet to be fully understood; it also dramatically responds to acute and chronic ...
(inability to produce enough growth hormone), chronic kidney disease, idiopathic short stature (unexplained shortness), Noonan syndrome, Turner syndrome, Prader-Willi syndrome (PWS), short stature homeobox-containing gene (SHOX) deficiency, and short stature born small for gestational age (SGA) with...
nano-lipid carriers of ganoderic acid in cancer prevention and treatment. Their molecular docking and pathway analysis found that ganoderic acid interfered effectively with various signaling proteins involved in cancer pathogenesis, thereby preventing progression of the disease. The study also found that...
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is a major c
Despite advances in noninvasive techniques for imaging the pancreaticobiliary system, several disease processes including indeterminate biliary strictures as well as neuroendocrine tumors, inflammatory pseudotumors, and complex cysts of the pancreas remain difficult to characterize. New endoscopic imaging techno...
Blood vessel problems or Cancer or Catheter insertion in the spine or Liver disease, moderate or severe or Lung problems (eg, bleeding, bronchiectasis, pulmonary cavitation), or history of or Stomach or bowel ulcer or bleeding or Stroke, recent or history of or Surgery (eg, eye, brain, spin...