Full size image Over the past 20 years, the link between JAK/STAT signaling and oncogenesis has become a major subject in cancer biology. It has long been known that STAT hyperactivity can drive cellular transformation downstream of classic oncogenes68. This hyperactivity, which typically involves ...
2020, Trends in Cell Biology Show abstract Proteomics and Metabolomics for AKI Diagnosis 2018, Seminars in Nephrology Show abstract Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site 2018, EMBO Reports Specificity of reversible ADP-ribosylation and regulation of cellul...
2021, Nature Reviews Molecular Cell Biology Parps and adp-ribosylation: Recent advances linking molecular functions to biological outcomes 2017, Genes and Development New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs 2012, Nature Reviews Molecular Cell Biology Family-...
Complete solution:The conversion might happen in the cytoplasm, which is the fluid between the cell membrane and the nucleus, or in mitochondria, which are specific energy-producing structures. ADP to ATP can be represented as ADP + Pi + energy ATP, or adenosine diphosphate plus inorganic ...
BMC Evolutionary Biology volume 13, Article number: 51 (2013) Cite this article 3572 Accesses Metrics details Abstract Background ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step in the synthesis of glycogen in bacteria and starch in algae and plants. In oxygenic ...
Full size image Figure 4 Schematic representation of domains found in PARP proteins. Proteins are arranged by clade as defined in Figure 1 and in the text (indicated on the left). The protein name is given on the right, with species in parenthesis. Numbers indicate amino acids. Protein domai...
Full size image Figure 4 Schematic representation of domains found in PARP proteins. Proteins are arranged by clade as defined in Figure 1 and in the text (indicated on the left). The protein name is given on the right, with species in parenthesis. Numbers indicate amino acids. Protein domai...
The H2O2-induced ADP-ribosylome profiled using AI-ETD largely resided on proteins with functional annotations that are well-known in the context of ADPr biology (Figure 2D;Table S5A). Taken together, AI-ETD is congruous with deep analysis of the ADP-ribosylome from a limited pool of start...
Download: Download full-size image Figure 2. Ectopic expression of the Nsp3 macrodomain reverses IFN-induced ADP-ribosylation. A, representative images of anti-FLAG immunofluorescence staining (green) and DAPI staining (blue) in A549 cells transduced either with an empty vector control (left) or ...
Lavrik 1,3,* 1 Institute of Chemical Biology and Fundamental Medicine, SB RAS, 630090 Novosibirsk, Russia; k-naumenko@mail.ru (K.N.N.); sukhanovamv@mail.ru (M.V.S.); t.a.kurgina@gmail.com (T.A.K.); lisenok.istreb@gmail.com (E.E.A.); kutuzov.mm@mail.ru (M.M.K.) 2...