In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid n
There are numerous exciting developments in this relatively young field of cancer immunotherapy. Following the success of immune checkpoint inhibitors–a topic touched upon in the November 2016 EBioMedicine editorial–all eyes are now on CAR T cells, which are being tested in more than 100 ongoing ...
Populations of T cells that are specific for tumour-associated antigens can be expanded to generate large numbers of cells and transferred into tumour-bearing hosts, a process known as adoptive cell transfer (ACT)-based immunotherapy. T cells can be genetically engineered to express αβ T cell...
Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of immunotherapy that redirect T cells to specifically target cancer. However, tumor antigen heterogeneity remains a key challeng
As an important part of the immune system, T lymphocytes exhibit undoubtedly an important role in targeting and eradicating cancer. However, despite these characteristics, their natural antitumor response may be insufficient. Numerous clinical trials in
Adoptive T-cell immunotherapyT- Ligand presentation 1. Introduction 1.1 Overview of adoptive T-cell immunotherapy Despite the advance in cancer therapeutics (e.g., surgery, chemotherapy, and radiotherapy) for improving the survival rate of cancer patients, the adverse effects of these therapeutics and...
Adoptive immunotherapy and dendritic cell immunotherapy are forms of cellular therapy, where ex-vivo processed cells are introduced into the body. Adoptive immunotherapy uses immune effector cells (e.g., T cells), whereas dendritic cell immunotherapy uses antigen-presenting cells. Pre-clinical studies ...
CAR tregsadoptive immunotherapyautoimmune diseasesregulatory T cellstransplantationRegulatory T cells (Tregs) are fundamental to maintaining immune homeostasis by inhibiting immune responses to self-antigens and preventing the excessive activation of the immune system. Their functions extend beyond immune ...
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both genetic and non-genetic approaches, facilitate the optimization of ad...
Populations of T cells that are specific for tumour-associated antigens can be expanded to generate large numbers of cells and transferred into tumour-bearing hosts, a process known as adoptive cell transfer (ACT)-based immunotherapy. T cells can be genetically engineered to express αβ T cell...