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导读嵌合抗原受体T细胞(Chimeric Antigen Receptor T-cell,CAR-T)疗法是一种新兴的细胞免疫治疗,通过基因工程改造T细胞,使其在细胞表面表达嵌合抗原受体(Chimeric Antigen Receptor T-cell,CAR)。这种受体赋予T细胞识别特定靶细胞表面抗原的能力,并能够对这些表达抗原的细胞介导特异性的细胞毒性反应。近年来,CAR-T...
2. June CH, O'Connor RS, Kawalekar OU, Ghassemi S, Milone MC. CAR T cell immunotherapy for human cancer. Science. 2018 Apr 27;359(6382):1361-1365. doi: 10.1126/science.aar6711. PMID: 29700230. 3. Zhang C, Liu J, Zhong JF, Zhang X. Engineering CAR-T cells. Biomark Res. 2017 ...
[1]Ganapathy T,et al.CAR γδ T cells for cancer immunotherapy. Is the field more yellow than green? Cancer Immunol Immunother. 2023 Feb;72(2):277-286. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992831/ ...
CAR-T 疗法就是嵌合抗原受体T细胞免疫疗法,英文全称 Chimeric Antigen Receptor T-Cell Immunotherapy。这是一种治疗肿瘤的新型精准靶向疗法,近几年通过优化改良在临床肿瘤治疗上取得很好的效果,是一种非常有前景的,能够精准、快速、高效,且有可能治愈癌症的新型肿瘤免疫治疗方法。T 细胞也叫 T 淋巴细胞,是人体白...
CAR-T(Chimeric Antigen Receptor T-Cell Immunotherapy),即嵌合抗原受体T细胞免疫疗法。该疗法是一种出现了很多年但近几年才被改良使用到临床中的新型细胞疗法。在急性白血病和非霍奇金淋巴瘤的治疗上有着显著的疗效,被认为是最有前景的肿瘤治疗方式之一。