While naloxone administration without indication has some complications and may put financial burden on the patient, it can also be considered a medical error. The aim of this study was to evaluate the frequency of pre-hospital naloxone administration without indication among poisoned patients. Methods...
Objective:To reveal the effects of different administration of naloxone on acute severe cerebral injuries.Methods:Forty eight patients with acute severe cerebral injuries(Glasgow Coma Scale 3～8,within 12 hours after injury) were selected for this study.According to the severity of injury,all patients...
in addition to financial incentives provided by the Orphan Drug Act (ODA), have led to hundreds of drug approvals for rare cancers.Research design and methodsUsing an internal US Food and Drug Administration
use of alternative methods for modeling substance abuse in animal subjects can only strengthen the ultimate goal of all researchers in this field, that being, of course, to more fully understand the behavioral and neurobiological factors that underlie and are responsible for drug abuse in our ...
Combinations of buprenorphine (0.4 or 0.8 mg/70 kg) and naloxone (0.4 or 0.8 mg/70 kg) reduced the sub jective and physiologic effects of buprenorphine in men who were not opiate dependent (Strain et al. 1992). Buprenorphine (0.4 mg/70 kg) in combination with 0.8 mg per 70 kg of...
Acute systemic and intracranial nicotine pretreatment limits the acquisition of conditioned place preference (CPP) to lower doses of morphine and cocaine11,29,30 and conditioned place avoidance from naloxone-precipitated morphine withdrawal31,32. Additionally, across multiple commonly abused substances, ...
Effective methods of extending the retention time in the nasal cavity are increasing the viscosity of the materials or using gel-like forms of drugs. Various biocompatible systems for the intranasal delivery of temozolomide werenanoemulsionand nanoemulsion gelling in situ. It was disclosed that the the...
Rats were tested for drug SA under a progressive ratio schedule with and without repeated predictable or unpredictable footshock over 8 weeks. Female rats consumed greater amounts of fentanyl than did male rats. Male rats exhibited greater withdrawal behaviors following naloxone challenge. Predictable ...
Both systemic and intra-VTA administration of the opioid receptor antagonist, naloxone, during the initial acquisition of sexual behavior experience prevents the long-term facilitation of both initiation and completion of sexual performance, without having an effect on mating behavior during the ...
By the end of the 20th century, nasal administration was the predominant route for the treatment of systemic diseases such as central nervous system, cardiovascular and cerebrovascular disorders [2]. Compared with other delivery methods, which were limited by invasiveness and blood-brain barrier (BBB...