Adjuvant olaparib in the subset of patients from Japan with BRCA1- or BRCA2-mutated high-risk early breast cancer from the phase 3 OlympiA trialAdjuvantEarly breast cancerBRCAOlaparibPARP inhibitorThe efficacy and safety of olaparib compared with placebo in the subset of patients from Japan in ...
The high incidence of breast cancer is the greastest threat to women’ health all over the world. Among them, HER-2 positive breast cancer has the characteristics of high malignancy, easy recurrence and metastasis, and poor prognosis. Traditional Chinese
hepatic and renal function CNS metastases allowed if no glucocorticoids or brain radiotherapy required, brain metastases stable ≤2 prior adjuvant/neoadjuvant chemotherapy regimens permitted (with exception of gemcitabine, carboplatin, cisplatin or a PARP inhibitor) R Gemcitabine + carboplatin + iniparib (...
Faculty Opinions recommendation of Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in t... A Prat - Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature 被引量: 0发表: 2018年 加载更多来源...
AstraZeneca's Lynparza (olaparib), a poly ADP-ribose polymerase (PARP) inhibitor, has been added to the Korean Breast Cancer Society’s (KBCS) practice guidelines, two months after expanding its indication to postoperative adjuvant therapy in adult patie
In this study, we showed that adding a caspase-2 inhibitor diminished apoptosis in poly(I:C)-transfected RCC cells, and that selective knockdown of caspase-2 inhibited both apoptosis and activation of caspase-3, -8, and -9 in poly(I:C)-transfected RCC cells. These results suggest that ...
A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tu... Veliparib is a potent small molecule inhibitor of PARP-1/2, which is cytotoxic in tumor cells with deficiencies in BRCA1 or BRCA2. We...
Moreover, to further confirm the effect of GOLPH3 on 5-FU-induced apoptosis, changes in cleaved PARP were detected by Western blot. PARP is a substrate of caspase- 3 and −7 which cleave it into 89 and 24 kDa fragments. Cleavage of PARP is one of the classic markers for activation ...
ES2853973T3|2021-09-20|Use of DNQ or DNQ-87 in combination with a PARP1 inhibitor for the treatment of cancer BR112020025760A2|2021-03-16|USE OF ALTERNATE ELECTRIC FIELDS TO INCREASE THE PERMEABILITY OF THE CELLULAR MEMBRANE Shao et al.2019|Auto-fluorescent polymer nanotheranostics for self-...
The chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l-fucose. Fucoidan has various biological and pharmacological activities, such as anti-cancer/anti-tumor, anti