PARP inhibitors in treatment of early stage breast cancer - ScienceDirectdoi:10.1016/S0960-9776(21)00075-8A. TuttThe Breast
784–786, 2009). AstraZeneca also shelled out $230 million for the PARP inhibitor olaparib in 2006 when it purchased one of the early pioneers in the
clinical trials are being conducted and have begun to yield results. For example, the POLO (Pancreatic Cancer Olaparib Ongoing) trial has demonstrated that the median progression-free survival was observably longer in the olaparib group than in the placebo group. However, PARP inhibitor resistance h...
Prostate cancer is the first disease where overall survival has been improved using a PARP inhibitor. Up until now, similarly to ovarian cancers [7], somatic and/or germinalBRCA 1and2aberrations seem to be the most predictive biomarkers of efficacy of PARPi. Data regarding the other HRR genes...
primarily via STING-dependent mechanisms in mice with BRCA1-deficient ovarian cancer. Furthermore, when combined with a PD-1 inhibitor, this effect is further intensified [87]. Additionally, certain studies have discovered that the treatment of ovarian cancer cells with talazoparib leads to a nota...
Conducted in 10 hospitals throughout the United Kingdom, the window study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (The RIO study; EudraCT 2014-003319-12, Cancer Research UK trial CRUK/12/034) was a single-group, open-label...
Learn more about LYNPARZA® (olaparib) as a PARP inhibitor for certain patients with certain types of Ovarian, Breast, Prostate or Pancreatic Cancer.
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Protein factors that influence PARPi trapping and/or inhibitor potency Resistance to PARPi PARPi in the context of genomic instability-driven inflammation Concluding remarks CRediT authorship contribution statement Declaration of competing interest Acknowledgements ReferencesShow full outline Cited by (7) Fi...
We suggest that the ADT and PARP inhibitor combination treatment is likely to be most effective in treatment of the early disease, rather than at the late CRPC stage. The HR mutated CRPC would not benefit as they already are defective in HR and would respond to PARP inhibitors in monotherap...