The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described ...
Some 47 serotypes are now known with five new ones (types 43–47) having been added to the list in the late 1980s, all of them found in the faeces of patients with AIDS. Their significance is unknown, as is type 42, which was a casual finding. This list may not be complete and ...
There i s a need f o r the r a p i d recognition of i n f e c t i o n by the newly-described enteral o r diarrhea-associated adenovi- ruses (adenoviruses t h a t are o f proposed neutralizing sero- t y p e s 4 0 and 41, o r t h a t have r e s t r i c...
There i s a need f o r t h e r a p i d recognition of i n f e c t i o n by the newly-described enteral o r diarrhea-associated adenovi- ruses (adenoviruses that are o f proposed neutralizing sero- t y p e s 4 0 and 41, o r t h a t have r e s t r i c t...
The invention provides a replication competent adenovirus, being capable of replicating and having lytic capacity in a host cell, the virus genome comprising at least one DNA sequence coding for a silencing factor functional in reducing expression and/or activity of a target gene in the host cell...
As a result they have been neglected recently, although they were one of the first viruses to be grown in tissue or cell culture. However, not all infections are benign and fatal childhood pneumonias have been described. They occasionally complicate transplants and they are overdue for a re-...
The invention thus provides chimeric adenoviruses having the useful properties of at least two adenoviruses of different serotypes. Typically, more than two requirements from the previously given non-exhaustive list are required to obtain an adenovirus capable of efficiently transferring additional material...
adenoviruses have also been described in applications Nos. WO94/26914 and FR 2,707,664, which are incorporated into the present application by reference. Then the adenoviruses which have multiplied are recovered and purified according to conventional molecular biology techniques, as illustrated in the...
The term “at least X % identity with Y” as used herein means that if a given nucleic acid or polypeptide sequence is aligned to a nucleic acid sequence Y or a polypeptide sequence Y, respectively, X % of the bases or amino acids within the aligned region are identical. X can be at...
The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described ...