Adeno associated virus and adenovirus chimeric recombinant viruses useful for the integration of foreign genetic information into the chromosomal DNA of target cellsChimeric viral vectors having both the capacity to infect host cells efficiently and the capacity to integrate their genomic material into the...
The meaning of ADENO-ASSOCIATED VIRUS is any of several single-stranded DNA viruses (genus Dependovirus of the family Parvoviridae) that enter the nucleus of a host cell but are dependent on coinfection with an adenovirus or herpesvirus for their replica
Adeno-associated virus enhances wild-type and oncolytic adenovirus spread. 来自 NCBI 喜欢 0 阅读量: 21 作者:E Laborda,C Puig-Saus,M Cascalló,M Chillón,R Alemany 摘要: The contamination of adenovirus (Ad) stocks with adeno-associated viruses (AAV) is usually unnoticed, and it has been ...
Adeno-associated virus (AAV) is a nonpathogenic parvovirus that efficiently replicates in the presence of adenovirus (Ad). Exogenous expression of the AAV replication proteins induces caspase-dependent apoptosis, but determining if AAV infection causes apoptosis during viral infection is complicated by Ad...
During adeno-associated virus and adenovirus (AAV/Ad) coinfection, accumulation of viral genomes and proteins can alter cellular stress responses. To determine how AAV/Ad coinfection affects the host we screened over 60 cellular proteins for their responses. AAV/Ad coinfections induce a robust DNA...
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administered via suprachoroidal injection at a higher do
Adena-associated virus Adeno-associated virus (AAV) is a member of the parvovirus family of single-stranded small DNA viruses that require a helper virus, such as adenovirus or herpes simplex virus for replication. Although the majority of the population is seropositive for AAV, the virus is no...
Vectors based on human adenovirus (Ad) and adeno-associated virus (AAV) are being evaluated for human gene therapy. The response of the host to the vector,... Chirmule,N,Propert,... - 《Gene Therapy》 被引量: 953发表: 1999年 Adeno-associated Virus Serotypes: Vector Toolkit for Human ...
Adenovirus and adeno-associated virus vector-mediated gene delivery is limited by the induction of a humoral immune response that prevents readministration. To determine whether viral delivery in the "preimmune" fetus would produce dose- or time-dependent tolerance, we evaluated the humoral immune res...
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineered for enhanc