Reports on the investigations connected with the death of Jesse Gelsinger, a patient of a gene therapy trial conducted by the University of Pennsylvania's Institute for Human Gene Therapy in Philadelphia. Results of the investigations; Implications of Gelsinger's death; Clues to what led to ...
The patient was the first in a gene therapy trial to die of the therapy itself; his death is the latest blow to a field that has been struggling to live up to the promise and hype surrounding the first gene therapy trials a decade ago.doi:10.1126/science.286.5448.2244...
In this review, a contemporary summarization of the current status of adenovirus-mediated p53 gene therapy of OS is presented. Advancement in our understanding of p53 tumor suppressor activity, the molecular biology of chemoresistant OS, and recent advances in tumor targeting with adenoviral vectors ...
These strategies and the use of adenoviral vectors for the treatment of hereditary, infectious, and malignant diseases of the liver are discussed in this review. 展开 关键词: adenoviral vectors gene therapy hereditary diseases infectious diseases hepatic malignancies ...
Influence of the bystander effect on HSV-tk/GCV gene therapy. A review. Curr Gene Ther 2002; 2: 307–322. CAS PubMed Google Scholar Jordan A, Scholz R, Wust P, Fahling H, Krause J, Wlodarczyk W et al. Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in ...
To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add...
Adenovirus-Based Cancer Gene Therapy Over the past decade, adenovirus (Ad)-based vectors have been used extensively in the context of cancer gene therapy. Two basic strategies have been pursue... Kaplan,Johanne - 《Current Gene Therapy》 被引量: 221发表: 2005年 Effective treatment of metastatic...
We discuss the potential of IL-12 gene therapy for prostate cancer in this review. 展开 关键词: Interleukin-12 prostate cancer orthotopic prostate cancer model in situ gene therapy metastasis DOI: 10.1007/0-306-48399-8_5 年份: 2001 收藏 引用 批量引用 报错 分享 ...
Gene therapy death prompts review of adenovirus vector For the past 3 months, faculty and staff members at the University of Pennsylvania9s Institute for Human Gene Therapy have been trying to understand why a ... E Marshall - 《Science》 被引量: 1650发表: 2000年 Cancer gene therapy using ...
development of effective rAd delivery vehicles is crucial, with criteria including high cellular infection rates, effective gene expression or replication, and the capability of carrier cells to target tumors. Of particular interest is the role of rAd in CAR-M therapy. Macrophages, critical players ...