This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and using such preparations, wherein the helper adenoviruses contain recombinase target sites that are useful in reducing the level of contamination of helper virus in helper-dependent ...
前言 2022年12月,FDA授予了Ferring Pharmaceuticals 的膀胱癌药物Adstiladrin® (nadofaragene firadenovec-vncg) 上市批准。Adstiladrin®是一种利用非复制型腺病毒载体的基因疗法(non-replicating adenoviral vector-based gene therapy)药物,...
However, there have not been reported studies on the lyophilization of live adenovirus for gene therapy. Generally it is assumed that adenovirus will not maintain its infectivity when stored at refrigerated condition in a liquid form for extended period of time. As a result, there are no ...
Adenovirus vectors can be replication-defective; certain essential viral genes are deleted and replaced by a cassette that expresses a foreign therapeutic gene. Such vectors are used for gene therapy, as vaccines, and for cancer therapy. Replication-competent (oncolytic) vectors are employed for ...
Lowenstein PR; Mandel RJ; Xiong WD;.Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of ... Pedro R. Lowenstein, Ronald J. Mandel, Wei-dong Xiong, Kurt Kroeger, Maria G. Castro - 《Current Gene Therapy》 被引量: 225发表: 200...
A method for producing in vivo packaged recombinant adenovirus vectors is provided. The recombinant Ad vectors do not contain any Adenovirus genes and are therefore useful for gene therapy. The recombinant Adenovirus vectors are packaged in vivo using a helper virus which is itself very inefficiently...
Adenovirus vectors for gene therapy 优质文献 相似文献Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy - Gao, Yang, et al. - 1996Gao, G. P., Y. P. Yang, and.....
Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. Development of adenovirus vectors as potential therapeutic agents for multiple applications of in vivo human gene therapy has resulted in numerous preclini...
The present invention relates to an adenovirus complex which can be utilized for gene delivery and gene therapy by targeting neurotensin receptors. The complex of the present invention has an excellent antitumor effect because of a high intracellular gene transfer efficiency and target specificity by ne...
The main obstacle to p53 gene therapy involves the limitations associated with current modes of delivery. Preclinical data strongly support the use of p53 gene transfer as a potential treatment for human gliomas. 展开 关键词:Apoptosis Gene therapy Gliomas p53 gene ...