FIRST IN HUMAN LUNG TRANSPLANTATION: ADENOSINE A2A RECEPTOR AGONIST (REGADENOSON)Background: Currently, no clinically available treatment exists for ischemia-reperfusion injury (IRI) following lung transplantation. Pre-clinical animal models have shown adenosine 2A receptor (A2AR) agonists are effective ...
After 4 h of activation, human T helper (Th) cells increased A2A adenosine receptor (A2AAR) mRNA level (sevenfold). A2AAR was the predominant subtype expressed in resting and stimulated gastric or peripheral Th cells. Stimulation with ATL313, an A2AAR agonist, increased cyclic AMP (cAMP) ...
The ACB is not only richly innervated by dopaminergic (DA) terminals but also exhibits the highest densities of adenosine A2a receptors in the brain. CGS 21680 (2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosine), a potent and highly selective adenosine A2a receptor agonist, ...
This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm...
cells were subjected to serum starvation conditions in DMEM with 1% FBS for the identified time. Cells were treated with 1 µM adenosine A2A receptor (A2AR) agonist CGS21680 for indicated time points (between 30 min and 3 h). In certain cases, A2AR antagonist ZM241385 at 1 µM was...
The effect of A2A adenosine receptor agonist (CGS-21,680) on the expression of BMP2, MMP8, and MMP9 in monocyte-generated macrophages from AS patients and controls. The data are presented as the mean ± SD Full size image MMP8 mRNA expression in AS patients’ M2-like macrophages aft...
产品描述 Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing. 信号通路 GPCR & G Protein 靶点 A2A adenosine receptor - - - - IC50 - - - - - 体外研究 Regadenoson produces hyperemia quickly and maintains it for a...
Influence of ligand binding on the conformation of adenosine A2A receptor (A2AR). (a) Representative structures (solid sticks) and evolution of the SCH 58261 antagonist (orange) and the CGS 21680 agonist (blue) in complex with A2AR (cylinders; only the initial structure is shown) during the...
an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation...
adenosine A2Apsychomotor disordersanxietydepressionObjective To explore the effects of gene knock-out,agonist or inhibitor of adenosine A2A receptor on the locomotor activity,and anxiety-or depression-like behavior of mice.Methods Male C57BL/6 mice,comprising those underwent gene knock-out of adenosine...