As part of the World ADC Series, the 2nd ADC Payload Summit returns to Boston to help you reimagine the medicinal chemistry of traditional cytotoxic payloads while scouting the next generation of ADC payload innovations. With novel payload categories such as degraders, RNA polymerase II inhibitors...
抗体偶联药物(Antibody-drug conjugates, ADC)是一类针对癌症的生物治疗药物,它结合了单克隆抗体(mAb)的靶向能力和细胞毒性药物(Payload,有效载荷)的抗癌能力。抗体和有效载荷通过连接子(Linker)进行连接,允许将特定药物递送至抗体靶向的癌细胞。ADC进入细胞后,连接的有效载荷被释放并杀死细胞(图1)[1]。虽然ADC旨在靶...
国内外知名企业ADC技术平台(第二期)-Mersana Therapeutics Inc. 抗体偶联药物(Antibody-drug conjugates, ADC)是一类针对癌症的生物治疗药物,它结合了单克隆抗体(mAb)的靶向能力和细胞毒性药物(Payload,有效载荷)的抗癌能力。抗体和有效载荷通过...
通过DoE研究，所有关键工艺参数(CPPs)的控制策略得以优化，包括物料比、混合率、pH、缓冲液交换等，而这些参数可能导致质量属性的不一致。图6：还原剂浓度作为CPP以减少聚集图7：氧化剂浓度作为CPP以达到最优DAR图8：研究药物载荷（Payload）以实现CQA目标 通过集成的实时在线分析提供了对工艺的完整理解，并使研究人员...
2. Sanjay Nilapwar, MedImmune, Developing an Efficient, Robust, and Scalable Conjugation Process for Bispecific ADC (BsADC), Bioprocessing Summit, Westin Copley Place, Boston 24 August 2017. 文末福利 扫描文章顶部二维码即可下载查看《生物过程下游工艺创新...
March 25-27, 2025 Boston, MA 4th ADC Analytical Development Summit April 28-30, 2025 | Boston, MA 2024 EVENT GUIDE PARTNER REGISTER INTEREST Accelerate Your Antibody-Drug Conjugate Pipeline to Become a Front-Line Treatment Antibody-drug conjugates are receiving unrivalled attention across the biophar...
March 25-27, 2025 Boston, MA 4th ADC Analytical Development Summit April 28-30, 2025 | Boston, MA 2024 EVENT GUIDE PARTNER REGISTER INTEREST Accelerate Your Antibody-Drug Conjugate Pipeline to Become a Front-Line Treatment Antibody-drug conjugates are receiving unrivalled attention across the biophar...
March 25-27, 2025 Boston, MA 4th ADC Analytical Development Summit April 28-30, 2025 | Boston, MA 2024 EVENT GUIDE PARTNER REGISTER INTEREST Accelerate Your Antibody-Drug Conjugate Pipeline to Become a Front-Line Treatment Antibody-drug conjugates are receiving unrivalled attention across the biophar...
March 25-27, 2025 Boston, MA 4th ADC Analytical Development Summit April 28-30, 2025 | Boston, MA 2024 EVENT GUIDE PARTNER REGISTER INTEREST Accelerate Your Antibody-Drug Conjugate Pipeline to Become a Front-Line Treatment Antibody-drug conjugates are receiving unrivalled attention across the biophar...
Back by popular demand, the 4th World ADC Asia Summit will unite the Asian-Based ADC Community to trailblaze innovation and collaborations