Methods Review of a sample of 102 subjects, 6 visits each, focused on accuracy of the 10 psychometric item scores for each ADAS-cog 13, the three global language ratings were not reviewed for accuracy. Not all errors were counted: Identifying Constructional Praxis errors was minimized as ...
Scores ranged from 0-39 (ADAS-Cog13), 0-27 (ADAS-Cog11), and 9-30 (MMSE). Estimates of CBB scores by COA scores showed expected associations between assessments. CBB composites for Accuracy and RT at MMSE > = 26 were estimated at approximately 0.7-0.9 and 2.8-2.6 respectively. SE in...
In designing clinical trials, the modified (13-item) ADAS-cog has been considered as a relatively sensitive assessment for disease progression. Analyzing the data of the MCI subjects from ADNI, we identified a subset of the ADAS-cog individual items with greater simplicity, improved sensitivity ...
Method Data from 13 multinational clinical trials of early symptomatic and mild to moderate AD were analyzed. ADAS-Cog and CDR assessments conducted by site raters were arranged according to visit sequence and divided into two groups: Rater Change (different raters administered subject'...
These suggest that a modified subscore weighting scheme applied to the 13-item ADAS-cog is comparable to imaging or CSF markers in prediction of conversion from MCI to AD at 12 months.doi:10.1097/WAD.0b013e3181f5b8d8Llano, Daniel A....
The post-modern world of Alzheimer’s disease trials: how much is an ADAS-cog point worth in central London? Int J Geriatr Psychiatry 2006; 21: 9–13Schneider LS. 2006. The post-modern world of Alzheimer's disease trials: how much is an ADAS-cog point worth in central London? Int J...
This study aims to explore psychometric features of ADAS-Cog (13 item ADNI version) in MCI and mild AD patients using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) and from there tailor a new "prodromal ADAS-Cog" (ProADAS-Cog) composite score that may be more ...
The cube was most frequently scored incorrectly (17 errors; 34%), followed by the rhombus (16 errors; 32%), overlapping rectangles (13 errors; 26%), and circle (4 errors, 8%). All figures generated statistically significant more errors than the circle (p < .0001). Raters erroneously ...
Methods: Utilizing ADNI data, we first compared the properties of the traditional 11-item ADAS-Cog (ADAS.11), the 13-item ADAS-Cog (ADAS.All) and novel composite scores from each of these tests, utilizing weighting schemes derived from a tree-based multivariate model called Random Forests (...
Participants with AD had MMSE of 13-26; those with MCI had MMSE of 24-30. We calculated the ADAS-cog11 score based on the original 11 items (range 0-70), the DR item score (range 0-10) and the ADAS-cog12 (range 0-80). We examined unadjusted and adjusted one-year change scores...