Intraplaque injection of p53 gene provides a safe and effective method for inducing plaque vulnerability in rabbits. The destabilizing effect of p53 overexpression is mediated mainly through apoptosis-enhanced inflammation rather than cell apoptosis itself....
a phase 2 trial of surgery with perioperative ingn 201 (ad5cmv-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx:objectivein patients with advanced squamous cell carcinoma of the head and neck (...
Carcinoma Cell Expression Lines1 in Two Human Jian-Hua Fei-Fei Departments Institute, Medical Toronto, Li, Liu2 Peixiang Li, Oncology Henry Klamut, and demonstrate therapy gations of this the in human efficacy NPC, of thus Ad5CMV-p53-mediated warranting additional gene investi- of Radiation P...
Cancer Gene TherapyCascallo M, Calbo J, Gelpi JL, Mazo A (2000) Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer. Cancer Gene Ther 7:545–556Cascallo M , Calbo J , Gelpi JL , et al. Modulation of drug cytotoxi2 city ...
The p53 tumour suppressor gene is deleted or mutated in many tumour cells and is one of the most frequently mutated genes in human tumours. INGN 201 has been shown to kill cancer cells directly.In August 2002, Introgen announced plans to file an application for INGN 201 with the European...
Purpose: The aim of this study was to investigate the efficacy of combination therapy of ionizing radiation (IR) and adenoviral p53 gene therapy and to evaluate its molecular mechanisms. Methods and Materials: Two human prostate cancer cell lines, DU145 and PC-3 cells, containing different types...