It remains unclear how the plasma AC profile reflects the AC content in tissues after different stimulus (glucose administration or exercise) and which tissues are responsible for changes in the plasma AC profile. Thus, in the present study, we investigated the changes in the AC profile in ...
4.2 Acylcarnitine profile Acylcarnitine profiles will also show inconsistent metabolites from the biotin-requiring enzymes, including propionylcarnitine (C3-carnitine) and 3-hydroxyisovalerylcarnitine (C5OH-carnitine). Low free carnitine is seen in plasma. View chapterExplore book 3-Methylglutarylcarnitine:...
Articles Basic Science Investigation nature publishing group Analysis and interpretation of acylcarnitine profiles in dried blood spot and plasma of preterm and full-term newborns Antonina Gucciardi1, Patrizia Zaramella2, Irene Costa1, Paola Pirillo1, Daniel Nardo2, Mauro Naturale1, Lino...
The objective was to determine the relationships between plasma acylcarnitines (ACs) and cardiometabolic risk factors in adults with and without CVDs. The AC profile in human plasma of healthy controls [non-CVD group, n=13)] and individuals diagnosed with CVDs (CVD group, n=34) were compared...
www.nature.com/scientificreports OPEN Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease Received: 7 May 2019 Accepted: 12 July 2019 Published: xx xx xxxx (NAFLD) and NAFLD-related hepatocellular carcinoma Kenichiro Enooku1, Hayato Nakagawa1, ...
Vianey-Saban C, Boyer S, Levrat V, Cheillan D, Piraud M, Guffon N, Maire I (2004) Interference of Cefotaxime in plasma acylcarnitine profile mimicking an increase of 3-hydroxypalmitoleylcarnitine (C16:1-OH) using butyl esters. J Inherit Metab Dis 27(Suppl 1):94 Google Scholar Young...
摘要: The acylcarnitine profile is a diagnostic test for inherited disorders of fatty acid and branched-chain amino acid catabolism. Patients with this type of metabolic disorder accumulate...关键词: Acylcarnitines tandem mass spectrometry inherited metabolic disease metabolomics fatty acid oxidation ...
Acylcarnitines are commonly used in the diagnosis of mitochondrial fatty acid beta-oxidation disorders (mFAODs). It is generally assumed that this plasma acylcarnitine profile reflects the mitochondrial accumulation of acyl-CoAs. The identity of the enzymes and the mitochondrial and plasmalemmal transport...
Plasma samples collected at baseline and after eight weeks of treatment with citalopram or escitalopram were profiled for short-, medium- and long-chain acylcarnitine levels using AbsoluteIDQ®p180-Kit and LC-MS. Linear mixed effects models were used to examine whether acylcarnitine levels ...
In whole blood sam- ples of 14 full-term infants, we found markedly higher levels of total (47.8 Ϯ 15.1 versus 37.8 Ϯ 9.7 mol/L) and long-chain acylcarnitines (7.1 Ϯ 2.3 versus 1.8 Ϯ 0.5 mol/L) compared with plasma. Because of these differences, carnitine levels ...