the organelle localization and the apparent kinetic constants ( K m and V max values) for the rat liver acyl-CoA: glycine- N-acyltransferase (glycine- N-acylase) toward isobutyryl-CoA, 2-methylbutyryl-CoA, isovaleryl-CoA, butyryl-CoA, hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA, and benzoyl-...
GlycineN-acyltransferase (GLYAT) is a member of the Gcn5-relatedN-acetyltransferase (GNAT) superfamily ofN-acyltransferases, which uses anacyl-CoAand glycine as substrates (Vettinget al., 2005; Schachter and Taggart, 1954). The products of the reaction are free CoA and an acylglycine, which ...
Reconstitution Calculator The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
This study presents characterisation of diatom'sPtLPCAT1 (acyl-CoA: lysophosphatidylcholine acyltransferase) activity in phospholipid remodelling. In this research microsomal fractions of yeast 螖ale1mutant overexpressingPtLPCAT1 were used as a source of the tested enzyme. In the assays evaluating ...
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands - Tanaka, Terasawa, et al. - 1998 () Citation Context ... screened a library of low-molecular weight ...
Novel N-(4-oxochroman-8-yl)amide derivatives 1 were synthesized and tested for their ability to inhibit rabbit small intestinal ACAT (acyl-CoA:cholesterol acyltransferase) in vitro and to lower serum total cholesterol in cholesterol-fed rats in vivo. Among the synthesized compounds, N-(7-alkoxy...
15 Tomoda, H., Tabata, N., Ito, M. & O¯ mura, S. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C. J. Antibiot. 48, 942–947 (1995). 16 Tomoda, H. et al. Amidepsine E, an ...
ˈfattiness n Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014 fat•ty1 (ˈfæt i) adj. -ti•er, -ti•est. 1. consisting of, containing, or resembling fat: fa...
C. et al. Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions. Circulation 110, 3372–3377 (2004). 30 Nissen, S. E. et al. Effect of ACAT inhibition on the progression of coronary athero- sclerosis. N. Engl. J. Med. 354, 1253...
Acyl-CoA cholesterol acyltransferase (ACAT) is the major enzyme responsible for esterification of intracellular cholesterol. We evaluated the ability of E5324 (n-butyl-N'-(-2-(3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxyl-6-methyl-phenyl)urea), a novel, orally absorbable ACAT inhibitor, ...