By this invention, novel nucleic acid sequences encoding for acyl-CoA:cholesterol acyltransferase (ACAT) related proteins are provided, wherein said ACAT-like protein is active in the formation of a sterol ester and/or triacylglycerol from a fatty acyl-CoA and sterol and/or diacylglycerol ...
Biological Activity YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo. Technical Data M.Wt: 452.63 Formula: C31H36N2O Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol ...
COA view current batch SDS Reconstitution Calculator Molarity Calculator Reconstitution Calculator The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine ...
Inhibitors of AcylCoA:cholesterol acyltransferase. Vaccaro W,Amore C,Berger J,et al. Journal of Medicinal Chemistry . 1996Fukuda T, Kitada Y, Chen XM, et al. Two new monoterpene glycoside from Ku-I)ing-Cha. inhibitors of Acyl CoA: cholesterol acyltransferase (ACAT)[J]. Chem Pharm Bull, ...
Twitter Google Share on Facebook fatty (redirected fromfatty acyl CoA:cholesterol acyltransferase) Dictionary Thesaurus Medical 1.containing, consisting of, or derived from fat 2.(esp of tissues, organs, etc.) characterized by the excessive accumulation of fat ...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "...
Selectivity of microbial acyl-CoA:cholesterol acyltransferase inhibitors toward isozymes. J Antibiot 60: 43–51 (2007) 15. Tomoda H, O¯ mura S. Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms. Pharmacol Ther 115: 375–389 (2007) ...
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of cholesterol. Two forms have been identified: ACAT1 is found ubiquitously in the endoplasmic reticulum of cells; ACAT2 is predominantly found in the endoplasmic reticulum of the liver and intestine. ACAT1 is sensitive to the...
目的研究人单核细胞系在佛波酯(PMA)作用下分化为巨噬细胞的过程中酰基CoA:胆固醇酰基转移酶1(ACAT1)活性的改变及其机制。 更多例句>> 5) cholesterol acyltransferase 胆固醇酰基转移酶 1. Objective: To investigate the effects of tetrandrine(Tet), a Chinese medicinal herb on expression of acyl-coenzyme ...
Oleoyl-CoA gave lower activity: 0.52 +/- 0.14 and 1.41 +/- 0.36, respectively. The variation with feeding and fasting was significant (P less than 0.05) and corresponded to that of the intestinal acyl-CoA:cholesterol acryltransferase (ACAT). Inhibition of retinol esterification was observed ...