Acyl halides and acid anhydrides react readily with water to give carboxylic acids. Esters react with water in an equilibrium reaction to give an alcohol and a carboxylic acid. Amides are stable to water under neutral conditions. The degree of completion of the reaction of an ester with water ...
The trichloromethyl benzoic acid esters can be made by the partial hydrolysis of the corresponding a ,a ,a ,a 1,a 1,a 1-hexachloroxylenes to the trichloromethyl benzoyl chlorides and conversion to an ester by heating with a primary alcohol. Alternatively the esters may be made by exhaustive...
The resulting compound represented by the formula ##EQU7## was optionally isolated and reacted with a salt of thiobenzoic acid or alkylxanthogenic acid in water or a proper organic solvent, for example, a lower alcohol or ethyl acetate at a low temperature to give an S-substituted compound...
where R1, R2, R3, R4 and n are as defined in formula (I) is reacted with a benzoyl halide of the formula (IV) ##STR5## where R5 and m have the meanings given in formula (I). The reactions of variants 1 and 2 are preferably carried out in an inert organic solvent in the ...
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hydroxy or mercapto esterified by an acid of 1-4 carbon atoms, halogen (F, Cl or Br), carboxyl, or carboxyl functionally modified by esterification with a lower alcohol of 1-3 carbons or by amidation. Preferably, the alkyl substituents are hydroxy or mercapto, either free or substituted by...
In a method for preparing a ketone of formula IVa, wherein Z is --CH2 -- and p is 1, a nitrile of formula VIII is treated with a suitable base, such as NaH, then reacted with a halide of formula IX to form a nitrile of formula X. Alternatively, the nitrile VIII is treated ...
with acetone/dichloromethane elution. The chromatographic fractions containing the second material eluted from the column were combined and evaporated to give the desired product, which was crystallized from isopropyl alcohol to give 0.98 g of product, as a brown solid, m.p. 133°-137° C. The ...