In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), an enzyme in the endoplasmic reticulum of cells found ubiquitously throughout the body, data recently obtained in at least three mammalian species, including nonhuman primates, mice and humans, demonstrate the presence of an ...
ACAT-2, a second mammalian acyl- CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem 273: 26755–26764 (1998) 6. Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL. Characterization of two human genes encoding acyl coenzyme A:cholesterol ...
Aβ production. Acyl-coenzyme A:cholesterol acyltransferase (ACAT), the enzyme that catalyses the formation of cholesteryl esters, modulates the generation of Aβ through the tight control of the equilibrium between free cholesterol and cholesteryl esters. We also show that pharmacological inhibitors ...
US5491172 * 1994年4月13日 1996年2月13日 Warner-Lambert Company Acylcoenzyme a:cholesterol acyltransferase inhibitorsUS5491172 Apr 13, 1994 Feb 13, 1996 Warner-Lambert Company Acylcoenzyme a:cholesterol acyltransferase inhibitorsUS5491172 * 1994年4月13日 1996年2月13日 Warner-Lambert Company N-acyl ...
Deficiency of acyl CoA:cholesterol acyltransferase 2 (ACAT2) in mice results in a reduction in cholesterol ester synthesis in the small intestine and liver, which in turn limits intestinal cholesterol absorption, hepatic cholesterol gallstone formation, and the accumulation of cholesterol esters in the...
(1995) Cheng et al. Journal of Biological Chemistry. Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the conjugation of long chain fatty acid and cholesterol to form cholesteryl esters. It is an integral membr
作者: N Sakashita,A Miyazaki,CCY Chang,TY Chang,E Kiyota,M Satoh,Y Komohara,PM Morganelli,S Horiuchi,M Takeya 展开 摘要: To test the possibility that acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) may be expressed in human macrophages under pathologic conditions, we employed specific ...
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S. Acyl coenzyme A:cholesterol acyltransferase inhibitors as hypolipidemic and antiatherosclerotic drugs. Methods Find. Exp. Clin. Pharmacol. 26, 563–586 (2004). 3 Miyazaki, A., Kanome, T. & Watanabe, T. Inhibitors of acyl-coenzyme A: cholesterol acyltransferase. Curr. Drug Targets Cardiovasc...
S. Acyl coenzyme A:cholesterol acyltransferase inhibitors as hypolipidemic and antiatherosclerotic drugs. Methods Find. Exp. Clin. Pharmacol. 26, 563–586 (2004). 3 Miyazaki, A., Kanome, T. & Watanabe, T. Inhibitors of acyl-coenzyme A: cholesterol acyltransferase. Curr. Drug Targets Cardiovasc...