Stoichiometric halocarbonylation of the ethylene–palladium(II) chloride complex proceeded under mild conditions to give 3-chloropropionyl chloride in quantitative yield. More generally, alkenes reacted directly with CO to afford 3-chloroacyl chlorides (equation 233).57,153 When hydrogen chloride was use...
PURPOSE:To prepare an acylcyanide useful as a pesticide, a highly selective acylating agent, a synthetic intermediate of heterocyclic compounds, etc., in high yield, in a short time, under mild conditions, by cyanogenating an acid halide with a cyano- tin compound. CONSTITUTION:The preparation...
Ethanoyl chloride reactsviolentlywith a cold concentrated solution of ammonia. A white solid product is formed which is a mixture of ethanamide (an amide) and ammonium chloride. ... Any hydrogen chloride formed would immediately react with excess ammonia to give ammonium chloride. Why is formyl ...
Acylsilane fr morpholine amide [rxn acylchloride] LiSiMe2Ph silylationLettan, R BMilgram, B CScheidt, K A
Transformation with sub- strates that contain an alkyl chain that bears a functionalizable polar group, such as an amide (10g), a silyl ether (10h) or a cyano unit (10i) proved to be exceptionally efficient (498% yield) and highly enantioselective (91:9–97:3 er). Rearrangements ...
Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of e
Alternatively, a specialised cyclase or transferase may be used which forms an amide bond, as in the pipecolate incorporating enzyme thought to be associated with the rapamycin PKS [1], or the amide synthetase found in the rifamycin PKS [2], [3]. In other PKS clusters, such as the type ...
This reaction can follow principles known to the skilled in the art for the formation of amides. The carbonyl compound of formula VII can be a carbonyl chloride or a carboxylic acid. The coupling with carboxylic acids as a rule makes use of the common coupling agents for amide bond formation...
N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem. J. 379, 99–106 (2004). 25. Petrosino, S. et al. Diacerein is a potent and selective inhibitor of...
(BrBOL, 4), were oligomerized in N,N-dimethylform- amide (DMF) or dimethyl sulfoxide at 25°C, through cleavage of the C(5)-0(8) bond and subsequent formation of the six-membered lactam ring, accompanied by the elimination of the alkali metal bromide, to give novel oligomers (5) ...