Laboratory investigation usually reveals high white cell count (WBC), promyelocytes and early myeloid series with abundant auer rods, with the exception of the microgranular variant. The bone marrow in APL is u
One cell has multiple Auer rods. (C) M3v APL (peripheral blood). Three basophilic blasts without granules show the typical bilobate nuclei. These cells were strongly positive for Sudan black, myeloperoxidase, and chloroacetate esterase. (Courtesy of Dr David Swirsky. Department of Haematology, ...
Lysosome derived structures in myeloid leukemia cells Auer rods (or Auer bodies) are large structures sometimes observed in AML, acute promyelocytic leukemia (APL), and myelodysplastic syndromes (Fig. 4). Auer rods are azurophilic, can resemble needles, commas, diamonds, rectangles, corkscrews, and...
But the really characteristic finding in APL is the faggot cell, so named because it contains atonof Auer rods all piled up on each other, resembling a bundle of sticks (or faggot). When you see these, you can make the diagnosis of APL based on morphology alone, without waiting for mole...
of Auer rods (‘faggots’) randomly distributed in the cytoplasm are almost invariably present in the bone marrow and sometimes in the peripheral blood. A variable but often high proportion of the hypergranular promyelocytes and the faggot cells are disrupted” [17]. Four years later, a ...
Acute Promyelocytic Leukemia PatientDerivative ChromosomeDear Sir, Acute promyelocytic leukemia (APL) is characterized by the translocation of chromosomal (15;17)(q22;q21) involving the fusion of the promyelocytic leukemia (PML) and RARA genes, resulting in a PML/RARA fusion gene on derivative ...
No Auer rods Large blasts (2–4 times the size of an RBC) Blasts with round or kidney-shaped nuclei that contain more cytoplasm than the blasts in ALL Prominent nucleoli Fine granules Leukemic hiatus: the presence of blasts and mature leukocytes but no intermediate forms Some subtypes (especi...
17 AML is further diagnosed by demonstrating the myeloid origin of these cells through testing for myeloperoxidase activity, immunophenotyping or documenting the presence of Auer rods. The latter finding consists of azurophilic, often needle-shaped cytoplasmic inclusion bodies that are commonly seen in ...
M3v phenotype is a less common presentation of APL and these patients usually present with leukocytosis and abnormal promyelocytes that are characterized by sparse granulation and are less likely to have faggot cells with multiple Auer rods. Distinguishing M3v phenotype from acute febrile illness ...
(E) and (F) Aspirate at (100×, oil) shows the morphologic characteristics of acute promyelocyte leukemia, enlarged nuclei with nucleoli, moderate cytoplasm with dense azurophilic granules and occasional Auer Rods. (For interpretation of the references to color in this figure legend, the reader ...