Acute Myeloid leukemia in the eld- erly is characterized by a distinct genetic landscape. Blood. 2015;126(23):804.Silva P, Neumann M, Schroeder MP, et al. Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape. Leukemia. 2017;31(7):1640-1644...
(Tapestri®, Mission Bio, Inc.) in primary samples from two patients with acute myeloid leukemia (AML)11. Here, using this method, we conducted scDNA-seq in 154 AML samples from 123 patients. In 26 of these patients, we have simultaneously profiled DNA and cell surface proteins. Our ...
Acute myeloid leukemia (AML) is a genetically heterogeneous, aggressive hematological malignancy induced by distinct oncogenic driver mutations. The effect of specific AML oncogenes on immune activation or suppression is unclear. Here, we examine immune responses in genetically distinct models of AML and...
Semantic Scholar Semantic Scholar (全网免费下载) 万方医学 dx.doi.org NCBI 查看更多 参考文献 引证文献Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperat... The associations of cytogenetics with complet...
Somatic heterozygous mutations of the nucleophosmin gene (NPM1)are the most frequent mutations in acute myeloid leukemia (AML)patients. Mutations occur in approximately one-third of alladult patients with AML and in one half of cytogeneticallynormal AML patients (CN-AML). Mutations are mostly ...
Immunophenotyping of acute myeloid leukemia cells 来自 NCBI 喜欢 0 阅读量: 10 作者: ED Ball 摘要: This article considers the expression of myeloid cell-associated antigens on both normal and malignant myeloid cells. Progress in the use of monoclonal antibodies to myeloid cell surface antigens ...
Myeloid/natural killer cell blast crisis representing an additional translocation, t(3;7)(q26;q21) in Philadelphia-positive chronic myelogenous leukemia We encountered a patient in blast crisis (BC) with chronic myelogenous leukemia (CML) who showed immunophenotypic features similar to those previously...
OBJECTIVE: Mutations of the nucleophosmin (NPM1) gene are considered as the most frequent acute myeloid leukemia (AML)- associated genetic lesion, reported with various incidences in different studies, and type A (NPM1-A) is the most frequent type. However, since most series in the literature...
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for the treatment of acute myeloid leukemia (AML). While clinical trials of MDM2 inhibitors have shown promise, responses have been confined to largely molecularly...
(such as DNA methylation and histone modifications) have been found to play an important role in this process, and they are currently therapeutic targets in acute myeloid leukemia (AML) and other hematologic malignancies2. We previously reported the complex regulation of some genetic mechanisms, ...