Acute Myeloid Leukemiabiomarkersgene mutationsDNA methylationprotein expressionAcute myeloid leukemia (AML) is the most common acute leukemia in adults. The pathophysiology of this disease is just beginning to be understood at the cellular and molecular level, and currently cytogenetic markers are the ...
This review summarizes the most relevant molecular (genetic, epigenetic, and protein) biomarkers associated with acute myeloid leukemia and discusses their clinical importance in terms of risk prediction, diagnosis and prognosis. 展开 关键词: Acute Myeloid Leukemia biomarkers gene mutations DNA methylation...
Acute myeloid leukemia( AML ) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. 急性髓性白血病 ( acutemyeloid leukemia, AML ) 是一类起源于造血干细胞的、以大量遗传缺陷为特征的异质性恶性血液病. 互联网 Methods: Induction regiment ofacute myeloid leukemia( AML ) co...
Acute Myeloid Leukemia (AML) is a bone marrow malignancy characterized by the infiltration of the bone marrow, blood and other tissues by clonal cells of the myeloid lineage with limited or no potential for differentiation [1]. From: Leukemia Research, 2022 ...
There are few molecular biologic determinants that are prognostic for patients with acute myeloid leukemia (AML). Hence, we examined whether cellular levels of the cyclin-dependent kinase inhibitor p27in acute myeloid leukemia could be used to predict clinical outcome in AML. Using immunoblot ...
Acute myeloid leukemia (AML) is a type of blood cancer that starts in your bone marrow, which is the soft inner part of your bones where all your blood cells are made. AML usually begins in cells that turn into white blood cells but can also start in other blood-forming cells. When ...
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain heterogeneous, and biomarkers for tailoring treatment are lacking. To understand how disease heterog
Acute Myeloid Leukemia (AML) in America 2023: Key Insights into Treatment Awareness & Satisfactionoffers a glimpse into the AML treatment experience. It includes selected insights for stakeholders seeking a more focused view of patient perspectives on AML ...
Related to acute myeloid leukemia:Chronic Myeloid Leukemia ThesaurusAntonymsRelated WordsSynonymsLegend: Switch tonew thesaurus Noun1. acute myeloid leukemia- acute leukemia characterized by proliferation of granular leukocytes; most common in adolescents and young adults ...
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for the treatment of acute myeloid leukemia (AML). While clinical trials of MDM2 inhibitors have shown promise, responses have been confined to largely molecularly...