Acute lymphoblastic leukemia (ALL) is a public health problem worldwide and is the leading cause of death in children under 14 years. Current ALL treatment is efficient in 80% of cases, but 5% of patients may relapse, with a life expectancy less than 5 years. Thus, the search for new ...
Acute lymphoblastic leukemia (ALL)—80%: of which 85% are B-cell acute lymphoblastic leukemia (B-ALL) and 15% are T-cell acute lymphoblastic leukemia (T-ALL) • Acute myeloblastic leukemia (AML), also known as acute nonlymphocytic leukemia—15% • Acute leukemias of ambiguous lineage—<...
Interleukin-7 receptor α (encoded byIL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-relatedIL7Rgain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutantIL7R, expressed at physiological levels in cond...
When discussing treatment options for patients with acute leukemia, it is important to acknowledge the impact of allogeneic hematopoietic cell transplantation (allo-HCT) or chemotherapy on quality of life (QOL). We performed a cross-sectional questionnai
The overall SAAIR was 57.6 per million children (95% CI, 46.9-68.3); acute lymphoblastic leukemia (ALL) was the most frequent type of leukemia, constituting 85.1% of the cases (SAAIR: 49.5 per million), followed by acute myeloblastic leukemia at 12.3% (SAAIR: 6.9 per million), and ...
Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy, accounting for approximately 80% of leukemia in the pediatric group, and its etiology is unknown. This neoplasia is characterized by male predominance, high-risk features and poor outcome, mainly in recurrence patients and adult...
Hematopoietic stem cell transplantation (HSCT) is considered an effective way to prevent relapse in adults with acute lymphoblastic leukemia (ALL). This st
The FDA has granted an orphan drug designation to EP0042 for use as a potential therapeutic option in patients with acute myeloid leukemia with acquired resistance to FLT3 inhibitors.
Acute lymphoblastic leukemia: Past and present Acute lymphoblastic leukemia (ALL) is a rare neoplasm in adults. Its treatment has seen dynamic developments ranging from the discovery of first compounds ... C Sálek,D Sponerová,JS Maaloufová - 《Vnitr̆ní Lékar̆ství》 被引量: 9发表:...
There were 2866 cases with AML, including 99 with APL, 408 with acute lymphoblastic leukemia, and 97 with acute undifferentiated/unclassified leukemia. This corresponds to 98% of all patients with acute leukemia in the Swedish Cancer Registry. Missing patients had a similar age and sex ...