life expectancyAcute myeloid leukemia (AML) can be diagnosed at any age and treatment, which can be given with supportive and/or curative intent, is considered expensive compared with that for other cancers. Despite this, no long-term predictive models have been developed for AML, mainly because...
A phase 1/2 trial evaluating DSP-5336 for the treatment of patients with acute leukemia harboring either an NPM1 mutation or KMT2A rearrangement showed early response rates. DSP-5336 delivered positive results in a recent ongoing, first-in-human, phase 1/2 study, particularly for patients wi...
Efficacy and Safety of Gemtuzumab Ozogamicin in Patients With CD33-Positive Acute Myeloid Leukemia in First Relapse Gemtuzumab ozogamicin (CMA-676, Mylotarg, an antibody-targeted chemotherapy agent, was recently approved by the FDA for the treatment of patients with CD33... EL Sievers - 《Expert ...
Decision-making and quality of life in older adults with acute myeloid leukemia or advanced myelodysplastic syndrome Older patients with acute myeloid leukemia (AML) and advanced myelodysplastic syndrome (aMDS) must decide between receiving intensive induction chemotherap... MA Sekeres,RM Stone,D Zahri...
9,26 Patients in remission from acute leukemia require less supportive care and hospitalization and have a better quality of life than patients during palliation. Remission, even if short-lived, is therefore a reasonable aim also in elderly patients. The consequences of intensive compared with ...
Long-term medical costs and life expectancy of acute myeloid leukemia: a probabilistic decision model. Value Health. 2014;17:205–14. Article PubMed Google Scholar Kantarjian HM, Thomas XG, Dmoszynska A, Wierzbowska A, Mazur G, Mayer J, et al. Multicenter, randomized, open-label, phase...
initiating leukemia resembling PAX5 P80R or Ph-like human B-ALL. Full transformation associates with transcriptional upregulation of oncogenes such asMycorBcl2, downregulation of tumor suppressors such asIkzf1orArid2, and major IL-7R signaling upregulation (involving JAK/STAT5 and PI3K/mTOR), requ...
Cytostatic Therapy of Chronic Myelogenous Leukemia: Review and Perspectives There is general agreement that life expectancy of patients with chronic myelogenous leukemia (CML) has not changed much during the past 60 years [15, 20, 28, 35, 41]. CML has remained uniformly fatal R Hehlmann 被引量...
Acute monocytic leukemia presenting as acute respiratory failure Am J Respir Crit Care Med, 167 (2003), pp. 1329-1333 View in ScopusGoogle Scholar 22 G Specchia, D Pastore, P Carluccio, et al. Pneumonia in acute leukemia patients during induction therapy: experience in a single institution Le...
Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed an...