In older patients, the prognosis remains very poor mainly because of resistance to chemotherapy otherwise poorly tolerated. Scores of geriatric comorbidities may help the therapeutic decision. Finally, deciphering genetics and epigenetics of acute leukemia cells revealed recurrent oncogenic abnormalities ...
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. ...
Acute lymphoblastic leukemiaALLprognosis in leukemiaOne hundred and twenty adult patients with acute lymphoblastic leukaemia were treated over a 10 year period with an intensive treatment protocol including induction with vincristine, prednisolone, adriamycin and L asparaginase, early intensification with 4 ...
The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndro... AG-013736 is an oral anti-angiogenesis agent with activity against a variety of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEG...
Related to acute myeloid leukemia:Chronic Myeloid Leukemia ThesaurusAntonymsRelated WordsSynonymsLegend: Switch tonew thesaurus Noun1. acute myeloid leukemia- acute leukemia characterized by proliferation of granular leukocytes; most common in adolescents and young adults ...
Treated secondary acute myeloid leukemia: A distinct high-risk subset of AML with adverse prognosis. Blood Adv. 2017, 1, 1312–1323. [Google Scholar] [CrossRef] Strickland, S.A.; Vey, N. Diagnosis and treatment of therapy-related acute myeloid leukemia. Crit. Rev. Oncol./Hematol. 2022, ...
Acute Myeloid Leukemia (AML) is a bone marrow malignancy characterized by the infiltration of the bone marrow, blood and other tissues by clonal cells of the myeloid lineage with limited or no potential for differentiation [1]. From:Leukemia Research,2022 ...
It mostly occurs in adults and is very rare in children. The prevalence is greater in men and in Caucasians. The classification system used for this leukemia is the Rai system, which is a clinical staging system based on absolute lymphocyte count and presence of lymphadenopathy, splenomegaly, ...
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The disease is clinically and genetically heterogeneous, and recent advances have improved our understanding of the cytogenetic abnormalities an...
Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols Article Open access 14 May 2024 Allogeneic hematopoietic stem cell transplantation overcome the poor prognosis of patients with IKZF1plus CD20–a very high-risk subtype in B-cell...