Enteral AT1aR antagonists are highly effective in preventing pro-inflammatory and histologic changes in a DSS colitis model. However, it is unclear which cell type mediates these pro-inflammatory changes: EC versus lymphoid. To address this question, we transplanted AT1aR knockout (KO) mouse ...
We investigated dietary squalene supplementation effect on an acute colitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice. Methods and results Mice were fed from weaning with squalene at 0.02% and 0.1%. After 4 weeks, mice were exposed to 3% DSS for 5 days developing acute...
Crohn’s disease (CD) and ulcerative colitis are two main clinically defined forms of chronic inflammatory bowel disease (IBD). Our understanding of IBD depends largely on rodent models. DSS-induced intestinal inflammation in mice and T cell transfer colitis in SCID mice are most widely used and...
Furthermore, 10G4 administration mitigates disease symptoms of mice in a dextran sulfate sodium (DSS)-induced model of acute colitis. This study illustrates that humanized monoclonal antibodies can be produced that target specific CysLTs and convey unique physiological properties that are of potential ...
Objective The aim of this study was to establish and evaluate (colour Doppler-) high-resolution-ultrasound (hrUS) and bench-top magnetic resonance imaging (btMRI) as new methods to monitor experimental colitis. Materials and methods hrUS, btMRI and endoscopy were performed in mice without coliti...
In this study, we aimed to investigate whether rhoifolin exerts its beneficial effects on colitis by modulating the process of epithelial ferroptosis.#Colitis model was successfully established in C57BL/6 mice through the administration of 2.5% dextran sulfate sodium (DSS) solution for a duration of...
The DSS colitis mouse model shares some thus not included in the sampling and analysis. Wt similarity to human ulcerative colitis (Okayasu (n ¼ 5) and STAT1 À / À (n ¼ 5) control mice of the et al., 1990), though it is rather a model for acute same age received DSS-...
Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. Eur. J. Pharm. Biopharm. 137, 112–121 (2019). Article CAS Google Scholar Coccia, M. et ...
Human inflammatory bowel disease and experimental colitis models in mice are associated with shifts in intestinal microbiota composition, but it is unclear at what taxonomic/phylogenetic level such microbiota dynamics can be indicative for health or dise
Fig. 5: Effect of oral administration of NZ-IL1Ra on DSS-induced colitis in model mice. Full size image Fig. 6: Anti-inflammatory effect of NZ-IL1Ra on cytokine expression. Full size image Effects of NZ-IL1Ra on the cecal microbiota in DSS-induced colitis ...