DSS colitis modelEosinophils were previously reported to play a role in intestinal inflammation and fibrosis. Whether this is as a bystander or as an active participant is still up for debate. Moreover, data describing a causal relationship between eosinophils and intestinal fibrosis are scarce. ...
An acute colitis model was induced with either dextran sulfate sodium (DSS) or trinitrobenzenesulfonic acid (TNBS) and a chronic colitis model was induced by CD4CD45RBT cell transfer from either wild-type C57BL/6 ormice. An anti-IL-17A antibody, secukinumab, was also used to inhibit IL-...
EXPERIMENTAL COLITIS IN RATS RESEMBLING HUMAN ULCERATIVE COLITIS We made acute colitis model with 5 %DSS and chronic colitis model with 2 % DSSEndoscopic, pathological and fecal bacteriologic findings of these models wer... Hiroshi,KOYAMA,Atsuhiro,... - 《Gastroenterological Endoscopy》 被引量: 7...
Methods Sixteen-month-old C57BL/6J and NLRP3 knockout (KO) mice received 1% wt/vol dextran sodium sulfate (DSS) in drinking water to model IBD. Colitis induction was confirmed by histopathology. Exploratory behavior was examined in the open field, associative memory by the novel-object ...
Gut inflammation was induced by exposure to dextran sodium sulfate (DSS) in the drinking water, a well-established rodent model of ulcerative colitis evoking prolonged inflammation. Neither acute (1 × 5 day cycle) nor chronic (3 × 5 day cycles) exposure to DSS affected fear ...
Induction of Colitis-associated Colorectal Cancer with Azoxymethane (AOM) and Dextran Sodium Sulfate (DSS) 6:36 Results 7:57 Conclusion 副本 The overall protocol describes easily performed surgical procedures of removing the appendix known as caecal patch in mice. The murin...
Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the digestive tract, which mainly includes Crohn’s disease and ulcerative colitis. Studies have shown that IBD patients have high susceptibility to develop colorectal cancer. Inflammatory mediators including cytokines (TNF-α, IL...
Lycopene could alter the composition of gut microbiome in dextran sodium sulfate (DSS) treated colitis mice by enhancing the relative abundances of Bifidobacterium and Lactobacillus and decreasing the relative abundances of the Proteobacteria [28]. In vitro Fermentation Model, an increasing abundance of ...
The DSS-induced chronic colitis model was characterized by reduced BW, high DAI, worsened histologic inflammation, and high levels of LPS and E. coli. Liver histopathological lesions, impaired liver function, enhanced proteins and mRNA levels of TNF-α, IFN-γ, IL-1β, IL-17A, TLR4, TRAF6 ...
To study IBD in mice, the most widely used model is dextran sulfate sodium (DSS)-induced colitis. The administration of 1–5% DSS in drinking water produces severe colitis that resembles human disease and is characterized by diarrhea, ulcerations, intestinal inflammation, body weight loss and ...