An object of the present invention is to provide a pharmaceutical composition for NK cell therapies expected to be highly effective. The present invention provides an NK cell having the following characteristics of (1) and (2) or a population thereof: (1) the NK cell is CD16-positive, ...
8,9,18]. Special phagocytic cells in the foreskin, Langerhans cells, are said to act as magnets to the virus which attaches to the cell and thus enters the body [19].
美[saɪtə'æktɪv] 英[saɪtə'æktɪv] n.细胞活性 英汉 网络释义 n. 1. 细胞活性 例句 释义: 全部,细胞活性
Objective Human invariant V[alpha]24+ natural killer T (NKT) cells, a subpopulation of NK cell-receptor (NKR-P1A)-expressing T cells with an invariant V[al... A Nicol,M Nieda,Y Koezuka,... - 《Experimental Hematology》 被引量: 0发表: 2000年 加载更多来源...
Target cell recognition, typically mediated by the T-cell antigen receptor (TCR) on CTLs or by activating NK receptors on NK cells, mobilizes these granules, which move toward the immune synapse (IS) and fuse with the synaptic membrane, releasing their contents into the intercellular space4. ...
DSA neurons are weakly excited by deep-layer pyramidal cells and strongly inhibited by several other GABAergic cell types. Spiking of DSA neurons modified the sequential firing order of other neurons at down–up transitions. Optogenetic activation of ID2+Nkx2.1+ interneurons in the posterior ...
Patients with multidrug-resistant TB had significantly lower fresh natural killer (NK) cell activity than matched controls with non-resistant pulmonary TB (P < 0.05). This was a specific abnormality, as there were no significant differences in antigen-specific cytotoxicity or lymphocyte proliferation ...
NK cellSynapseActivationSignalCytoskeletonPrior to delivery of a lethal hit, NK cells form an immunological synapse to scan the target cells and engage their activatory and inhibitory receptors. Using freshly isolated NK cells, IL-2-activated polyclonal NK bulk or the NKL cell line, we report ...
(NK) cell line31(YT-1) and assessed STAT5 phosphorylation as a readout for IL-2 signaling (Fig.2c). Selective activation was observed for the targeted Neo2A–Neo2B pair (Fig.2dand Extended Data Fig.5a) but required a high ratio (20:1) of tumor cells to immune cells. We ...
Chronic active Epstein-Barr virus infection (CAEBV) is a syndrome that takes diverse clinical courses and is often associated with lymphoproliferative disorders of T/natural killer (NK)-cell lineage. We describe a patient with CAEBV associated with persistent pharyngeal ulcer, and with subsequent nasal...