Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines. Dermatoendocrinol 2009;1:232-8.Sertznig P, Seifert M, Tilgen W, Reichrath J (2009) ...
Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-(3)H vitamin D(3) into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the ...
Objective: Previous studies from our laboratory have shown that the active form of vitamin D, 1,25(OH)2D3, can induce an antibacterial innate immune response in gingival epithelial cells (GECs), including the induction of genes encoding LL-37, TREM-1, and CD14. We also observed that the ...
The potentially protective role of vitamin D receptor activation in the inflammatory processes regarding the long-term outcomes in CKD patients warrants further studies. SOLID study;NCT01204528, April 27, 2010. 展开 关键词: Chronic kidney disease Endothelial function Inflammation VEGF Micro RNA ...
intracellular load ofMtbby secretion ofβ-defensin-2 and activation of vitamin D receptor pathway.6Similar to hypoxia, classical activation of macrophages also shift metabolism toward glycolysis.7This phenomenon of glycolytic shift is also required for the activation of other immune cells specifically ...
Activity of vitamin D receptor agonists against dengue virus Janejira Jaratsittisin Bin Xu Duncan R. Smith Scientific Reports (2020) Download PDF Sections Figures References Abstract Main Results Discussion Materials and Methods Abbreviations References Acknowledgements Author information Ethics declarations...
Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD), partly due to endothelial dysfunction and chronic inflammation. Vitamin D treatment in end stage renal disease is suggested to modulate the immune system and lead to im
Vitamin D-interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the estrogen receptor (ER) and other nuclear receptors (NRs). In ZR-75 breast cancer cells treated with 17β-estradiol (E2) and transfected with a construct containing three tandem estrogen re...
Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy A majority of HIV-1-infected patients present a severe deficit in vitamin D, which predicts short-term mortality. Vitamin D is a naturally synthesized horm......
doi:10.1038/ni0111-3bCarsten GeislerNature Immunology