Vitamin D Receptors (VDRs) are present in several systems and tissues and VDR activation is associated to positive effects, resulting in better blood pressure control and prevention of diabetic nephropathy. Unfortunately, the natural, non-selective vitamin D receptor activator (VDRA), calcitriol, is...
1α,25-dihydroxyvitamin D3 (calcitriol), the bioactive metabolite of vitamin D, modulates the activation and inhibits IgE production of anti-CD40 and IL-4 stimulated human peripheral B cells. Engagement of CD40 results in NF-κB p50 activation, which is essential for the class switch to IgE....
The kidney is also essential for the uptake of 25D from the glomerular ultrafiltrate for its recycling to the circulation to maintain serum 25D levels, extrarenal calcitriol synthesis, and the prosurvival benefits of autocrine/paracrine VDR activation. Indeed, both calcitriol and vitamin D ...
Mutations in the AF2 domain abolish vitamin D-dependent transactivation but do not affect constitutive activation by Ets-1. Therefore, in contrast with the actions of vitamin D, activation by Ets-1 is independent of the AF2 domain. Ets-1 also conferred a ligand-independent activation to the ...
- 《Journal of Clinical Investigation》 被引量: 175发表: 2011年 Vitamin D Enhances Caspase-Dependent and Independent TNF-Induced Breast Cancer Cell Death : The Role of Reactive Oxygen Species Abstract: Calcitriol, the hormonal form of vitamin D, enhanced TNF-induced cytotoxicity in MCF-7 breast ...
190: BXL-628, a Vitamin D Analog, Decreases RHOA/ROK Signalling in Rat and Human Bladder According to all the consensus and statements of the major societies, hypogonadism should be considered a medical problem, termed late onset hypogonadism (... A Morelli,S Filippi,R Mancina,... - 《Jour...
We previously described a distinct set of ligand-dependent proteins called DRIPs, which interact with the vitamin D receptor (VDR); together, these proteins constitute a new cofactor complex. DRIPs bind to several nuclear receptors and mediate ligand-dependent enhancement of transcription by VDR and ...
Vitamin A and retinoid signaling: genomic and nongenomic effects. J. Lipid Res. 54, 1761–1775 (2013). 29. Zhou, H. et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell 17, 560–573 (2010). 30. Cantley, L. C. The ...
divided into four groups: (1) Nx+vehicle group, treated with vehicle; (2) Nx+PDTC prevention group, treated with NF-κB inhibitor PDTC for 2months; (3) Nx+PDTC therapy group, treated with PDTC for 1month; (4) Nx+calcitriol group, treated with activated vitamin D calcitriol for 1month...
P4HB catalyzes the formation of 4-hydroxyproline in collagen [49] while PDIA3 interacts with calcitriol, an active form of vitamin D3, which could regulate gene expression through binding to the nuclear receptor vitamin D receptor (VDR) in cells [50]. Interestingly, genetic polymorphism of ...