By contrast, common nevi harboredBRAFV600Ein 7/10,NRASQ61Rin 3/10, with no additional identified mutations. Thus DPN are genetically defined by the combination of MAPK activating and β-catenin activating mutations and are distinct from common and blue nevi. ...
Furthermore, we examined the upstream signaling pathway involved in the induction of CCL4 expression by SRF, and confirmed that activation of p38 and ERK, which are part of the MAPK pathway, are involved. These results suggest that methylmercury induces the expression of CCL4 by activating SRF ...
p38 MAPK is activated potently during cardiac ischaemia, although the precise mechanism by which it is activated is unclear. We used the isolated perfused rat heart to investigate the signalling pathways activated upstream of p38 during global cardiac ischaemia. Ischaemia strongly activated p38α but ...
Hypothalamic inflammation has been demonstrated to be an important mechanism in the pathogenesis of obesity-induced type 2 diabetes mellitus. Feeding pregn... Eva,Rother,Ruth,... - 《Endocrinology》 被引量: 101发表: 2012年 Activation of MAPKs in the anti-β2GPI/β2GPI-induced tissue factor ...
Figure 2. Effect of TAB2 on the Kinase Activity of TAK1 (A) Effects of TAB1 and TAB2 on TAK1 kinase activity in yeast cells. Yeast strain SY1984 was transformed with an expression vector encoding TAK1-HA and expression vectors encoding either TAB1 or TAB2 as indicated. TAK1-HA was ...
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biolo...
Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration-resistant prostate cancer, is key for its activity as transcription factor, allowing it to translocate to the nucleus and partition into transcriptional condensates upon ...
Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway Stimulation of a variety of cell surface receptors enhances the enzymatic activity of mitogen-activated protein kinases (MAPKs). MAPKs have been class...
The effect of the unfamiliar taste was specific to the insular cortex. Jun N-terminal kinase 1-2 (JNK1-2) was activated by drinking the taste but with a delayed time course, whereas the activity of Akt kinase and p38MAPK remained unchanged. Elk-1, a member of the ternary complex factor...
the understanding of their intracellular signaling pathways in the brain is a main goal in biomedical sciences. Several straightforward methods exist to measure the functionality of these receptors in vitro. However, measuring GPCR activity in native tissue is still a challenge, which is mainly due ...