Nuclear actin, in complex with Arp4, forms an essential subunit of several nucleosome remodeler complexes, including INO80C, which facilitates DNA polymerase elongation. Here we show that the genetic ablation of INO80C activity leads to partial YCS resistance, suggesting that elevated levels of ...
Starting with the basics of actin dynamics from a structural perspective and building upon this from recent studies that help understand self-regulatory systems, we try to provide context to intracellular studies of actin dynamics, especially as they relate to the formation of cofilin-actin rods. ...