The actin cytoskeleton, membrane lipid microdomains and T cell signal transduction. Morley SC,Bierer BE. Advances in Immunology . 2001Morley, S. C., Bierer, B. E. (2001) The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction. Adv. Immunol. 77, 1- 43....
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the rece...
We term this cell death disulfidptosis. Chemical proteomics and cell biological analyses showed that glucose starvation in SLC7A11high cells induces aberrant disulfide bonds in actin cytoskeleton proteins and F-actin collapse in a SLC7A11-dependent manner. CRISPR screens and functional studies ...
4.5.1.1The Actin Cytoskeleton The actincytoskeletonis a highly heterogeneous and composite intracellularbiopolymernetwork. The cell utilizes a number of different actin structures with distinct architectures and compositions for diversebiological processes, such as cell division, migration, and regulation of ...
Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle β- and γ-actin, also known as cytoplasmic actin, are ubiquitously expressed, controlling cell structure and motility (1). While all actin isoforms are high...
HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells Alexander Weidemann, Johannes Breyer, Margot Rehm, Kai-Uwe Eckardt, Christoph Daniel, Iwona Cicha, Klaudia Giehl & Margarete Goppelt-Struebe Cell Communication and Signal...
We have previously identified several PIM substrates, which support cancer cell migration and invasiveness. However, none of them are known to regulate cellular movements by directly interacting with the actin cytoskeleton. Here we have studied the phosphorylation-dependent effects of PIM1 on actin ...
Wilson C. et al. 2016. Actin filaments-A target for redox regulation.Cytoskeleton (Hoboken). 73, 577-595. Lundquist M.R. et al. 2014. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.Cell. 156, 563-576. Yoon J. et al. 2017. Amplification of F-Actin disassembly...
Actins are a key part of the cytoskeleton and are involved in cell motility, structure, and signaling, with beta-actin as part of the contractile apparatus. Beta-actin is located in the cytoplasm of non-muscle cells, particularly where the plasma membrane meets the cytoskeleton (PMID: 1993736...
Cellular locationCytoplasm, cytoskeleton Customer validationWB (Human, unknown, Mouse, Tongue sole, Murine, Pacific oyster, Rat, Human, Citrus sinensis, Pig, grass carp); IP (Human); IF (Human, Mouse); IF (Human); IHC (Human) About the Immunogen ...