研究报道乙酰辅酶A合成酶2(Acetyl-CoA synthetase 2,ACSS2)既可利用肠道来源的短链脂肪酸-乙酸生成乙酰辅酶A、也可促进组蛋白赖氨酸残基间乙酸盐的直接转移,促进组蛋白乙酰化介导的学习记忆相关基因的转录诱导[7, 9]。但ACSS2及底物乙酸是否参与AD脑内组蛋白乙酰化介导的突触可塑性的调控尚不清楚。 2023年7月12日...
研究报道乙酰辅酶A合成酶2(Acetyl-CoA synthetase 2,ACSS2)既可利用肠道来源的短链脂肪酸-乙酸生成乙酰辅酶A、也可促进组蛋白赖氨酸残基间乙酸盐的直接转移,促进组蛋白乙酰化介导的学习记忆相关基因的转录诱导[7, 9]。但ACSS2及底物乙酸...
In mammalian cells, ACSS2 utilizes intracellular acetate to synthesize acetyl-CoA, a step in the process of DNA and histone acetylation. In addition, studies in tumors have shown that cancer cells adapt to the growth conditions in the tumor microenvironment (TME) by activating or increasing the ...
指标别名ACAS2;AceCS;Acetate CoA ligase;Acetyl CoA synthetase;ACS;ACSA;ACSS2;Acyl activating enzyme 克隆性Polyclonal 检验物种human,mouse,rat 应用范围WB,ICC,IF 基因名称ACSS2 抗体来源Rabbit 抗体类型IgG 计算分子量79kDa 成分Rabbit IgG,1mg/mL in PBS with 0.02% sodium azide,50% glycerol,pH7.2 ...
Acetyl coenzyme A (acetyl-CoA) is the acetyl donor for Lys acetylation reactions in mammalian cells. Histone Lys acetylation promotes transcription and is regulated by the metabolic state of the cell, but it is unclear how it is maintained during metabolic stress when sources of acetyl-CoA, ...
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-bin...
ACSS2 (Acetyl-coEnzyme A Synthetase, Cytoplasmic, Acetate-CoA Ligase, Acetyl-CoA Synthetase, ACS, AceCS, Acyl-CoA Synthetase short-Chain Family Member 2, Acyl-Activating Enzyme, ACSS2, ACAS2)化学性质安全信息ACSS2 (Acetyl-coEnzyme A Synthetase, Cytoplasmic, Acetate-CoA Ligase, Acetyl-CoA ...
Activation of AMPK is reflected by its substrate acetyl-CoA carboxylase (ACC) S79 phosphorylation. WT and AMPKa1/2 DKO MEFs were deprived of glucose for 1 hr. Total cell lysates were prepared. U87 cells expressing the indicated FLAG-ACSS2 proteins were deprived of glucose for 1 hr. Immuno...
ACSS2 基因功能 This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regul...
基于以上模拟对接结果,作者认为VY-3-135占据AcCoA合成酶的乙酰-AMP和CoA结合口袋可阻止底物结合和AcCoA合成。 Figure2.Model of Salmonella enterica acetyl-CoA synthetase in complex with VY-3-135.(A) Amino acid sequence alignment of...