In mammalian cells, ACSS2 utilizes intracellular acetate to synthesize acetyl-CoA, a step in the process of DNA and histone acetylation. In addition, studies in tumors have shown that cancer cells adapt to the growth conditions in the tumor microenvironment (TME) by activating or increasing the ...
研究报道乙酰辅酶A合成酶2(Acetyl-CoA synthetase 2,ACSS2)既可利用肠道来源的短链脂肪酸-乙酸生成乙酰辅酶A、也可促进组蛋白赖氨酸残基间乙酸盐的直接转移,促进组蛋白乙酰化介导的学习记忆相关基因的转录诱导[7, 9]。但ACSS2及底物乙酸是否参与AD脑内组蛋白乙酰化介导的突触可塑性的调控尚不清楚。 2023年7月12日...
指标别名ACAS2;AceCS;Acetate CoA ligase;Acetyl CoA synthetase;ACS;ACSA;ACSS2;Acyl activating enzyme 克隆性Polyclonal 检验物种human,mouse,rat 应用范围WB,ICC,IF 基因名称ACSS2 抗体来源Rabbit 抗体类型IgG 计算分子量79kDa 成分Rabbit IgG,1mg/mL in PBS with 0.02% sodium azide,50% glycerol,pH7.2 ...
研究报道乙酰辅酶A合成酶2(Acetyl-CoA synthetase 2,ACSS2)既可利用肠道来源的短链脂肪酸-乙酸生成乙酰辅酶A、也可促进组蛋白赖氨酸残基间乙酸盐的直接转移,促进组蛋白乙酰化介导的学习记忆相关基因的转录诱导[7, 9]。但ACSS2及底物乙酸...
抗体名称 Anti-Acetyl CoA synthetase/ACSS2 Antibody 指标别名 ACAS2;AceCS;Acetate CoA ligase;Acetyl CoA synthetase;ACS;ACSA;ACSS2;Acyl activating enzyme 克隆性 Polyclonal 检验物种 human,mouse,rat 应用范围 WB,FCM,ELISA 基因名称 ACSS2 抗体来源 Rabbit 抗体类型 IgG 免疫原 E.coli-derived human ACSS2...
[2]Schug Z T, Peck B, Jones D T, et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress[J]. Cancer Cell, 2015, 27(1): 57-71. [3]Miller K D, O’connor S, Pniewski K A, et al. Acetate acts as a metabolic immunomodula...
论文通信作者、宾夕法尼亚大学佩雷尔曼医学院细胞与发育生物学系教授Shelley L. Berger博士说,“在学习之后,这种被称作乙酰辅酶A合成酶2(acetyl-CoA synthetase 2, ACSS2)的酶促进神经元的细胞核中的整个基因表达复合体‘在现场’开启关键的记忆基因。我们发现ACSS2的直接结合基因和它在调节学习和记忆的神经元中发...
3、乙酰辅酶a合成酶2(acetyl-coasynthetase2,acss2)是acss家族的重要成员,可催化乙酸盐转化为能量代谢重要中间代谢产物—乙酰辅酶a。在代谢方面,acss2已经被证实可以抑制体内脂质的合成,也有研究指出胰岛素可以正向调节acss2的表达。同时acss2不仅是能量代谢关键酶,也是多种蛋白翻译后修饰底物的限速酶,可以催化丁酸、巴...
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-bin...
Activation of AMPK is reflected by its substrate acetyl-CoA carboxylase (ACC) S79 phosphorylation. WT and AMPKa1/2 DKO MEFs were deprived of glucose for 1 hr. Total cell lysates were prepared. U87 cells expressing the indicated FLAG-ACSS2 proteins were deprived of glucose for 1 hr. Immuno...