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Reactive oxygen species (ROS)p38 MAPKWe sought to explore the fate of the fatty acid synthesis pathway in human fibroblasts exposed to DNA damaging agents capable of inducing senescence, a state of irreversible growth arrest. Induction of premature senescence by doxorubicin or hydrogen peroxide led ...
to produce ATP and carbon precursors and as nitrogen donor forbiosynthesisofmacromolecules. This pathway also contributes to maintain redoxhomeostasisand reducesROSproduction. Moreover, glutaminolysis has a role in epigenetic and metabolic rewiring of cancer cells by generating α-KG and acetyl-CoA. For...
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Depletion of the cellular pool of palmitic acid is associated with induction of apoptosis concomitant with the formation of reactive oxygen species (ROS) and mitochondrial impairment. Expression of a small interfering RNA (siRNA)-resistant form of ACCalpha mRNA prevented the effect of ACCalpha-RNAi ...
乙酰辅酶 A 广泛存在于动物、植物、微生物和培养细胞中。是生物体能源物质代谢过程中 产生的一种重要的中间代谢产物。在体内能源物质代谢中是一个枢纽性的物质。糖、脂肪、 蛋白质三大营养物质通过乙酰辅酶 A 汇聚成一条共同的代谢通路-三羧酸循环和氧化磷酸 ...
The ROS-dependent peroxidation of polyunsaturated fatty acids (PUFAs) in cell membranes is the cause of ferroptosis, while downstream products of acetyl-CoA in the DNL pathway (CoQ) or MVA pathway (squalene) may play important roles in preventing ferroptosis of cancer cells [26]. Ubiquinol (...
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Taken together, the classes of proteins and the changes in regulation in the b1 and b2 mutants suggest that CK2 has a central role in mitochondrial metabolism, secondary metabolism, and reactive oxygen species (ROS) resistance, in addition to its previously suggested role in the formation of new...
Roschitzki, S. Mohanty, E.M. Niederer, E. Laczko, E. Timmerman, V. Lange, E. Hafen, R. Aebersold, J. Vandekerckhove, K. Basler, C.H. Ahrens, K. Gevaert, E. Brunner Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster Plos Biol...