Acetyl-CoA carboxylase ICellular senescenceDNA damage responseReactive oxygen species (ROS)p38 MAPKWe sought to explore the fate of the fatty acid synthesis pathway in human fibroblasts exposed to DNA damaging agents capable of inducing senescence, a state of irreversible growth arrest. Induction of ...
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Depletion of the cellular pool of palmitic acid is associated with induction of apoptosis concomitant with the formation of reactive oxygen species (ROS) and mitochondrial impairment. Expression of a small interfering RNA (siRNA)-resistant form of ACCalpha mRNA prevented the effect of ACCalpha-RNAi ...
to produce ATP and carbon precursors and as nitrogen donor forbiosynthesisofmacromolecules. This pathway also contributes to maintain redoxhomeostasisand reducesROSproduction. Moreover, glutaminolysis has a role in epigenetic and metabolic rewiring of cancer cells by generating α-KG and acetyl-CoA. For...
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乙酰辅酶 A(Acetyl-CoA)含量测定试剂盒说明书 微量法 100 管/96 样 正式测定前务必取 2-3 个预期差异较大的样本做预测定 测定意义 乙酰辅酶 A 广泛存在于动物、植物、微生物和培养细胞中。是生物体能源物质代谢过程中 产生的一种重要的中间代谢产物。在体内能源物质代谢中是一个枢纽性的物质。糖、脂肪、 ...
Targeting acetyl-CoA metabolism is an efficient approach for cancer treatment. Abstract Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub for the biosynthesis of fatty ...
It seems that ALC can enhance oxidative cerebral energy production, decrease anaerobic glycolysis, and reduce lactic acidosis by providing acetyl groups for the acetyl-CoA synthesis that can enter the citric acid cycle. Reduction in brain lactic acidosis that significantly affects ROS formation is one...
Recently, many works suggest that nonenzymatic lysine acetylation on protein mediated by the reactive, high-energy metabolite acetyl-phosphate or by acetyl-CoA44. From a transcriptomic perspective, S. halodurans H3B36 may not be the only species in the Staphylococcaceae to recruit lysine ...
Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (N-Acetylcysteine,616-91-1) 是一种粘液溶解剂 (mucolytic agent),可用于减少粘液的厚度。Acetylcysteine 是一种 ros抑制剂。Acetylcysteine 是半胱氨酸前体,通过中和花生四烯酸依赖的 5-脂氧合酶活性所产生的毒性脂质来防止血红素诱导的铁中毒 (ferroptosis)。