Therefore, it is possible that H3K56ac lowers the binding energy between DNA and histones at the entry and exit point of the nucleosome and thereby enhancing the activity of these chromatin remodelers. Alternatively, H3K56ac, like other modifications, may directly interact with ISWI family ...
Therefore, it is possible that H3K56ac lowers the binding energy between DNA and histones at the entry and exit point of the nucleosome and thereby enhancing the activity of these chromatin remodelers. Alternatively, H3K56ac, like other modifications, may directly interact with ISWI family ...
1998. Acetylation reduces the nuclease activity of Fen1 because it lowers its DNA binding affinity. p300 was also reported to form a complex with thymine DNA glycosylase (TDG) (Tini et al., 2002). This interaction stimulated CPB-dependent transcription and induced acetylation of TDG which, in ...
Rgs2, a key G-protein regulator, lowers blood pressure in a complex process decreasing signaling through Gαq. This protein is involved in regulation of stress responses, hormones, translation, Ca2 + channels, cardiac rhythms and cardiovascular homeostasis [91], [92], [93], [94], [95], ...
et al. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metab. 20, 898–909 (2014). Article CAS PubMed PubMed Central Google Scholar White, P. J. et al. The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-...
(NRD) of c-Myb by p300 or CBP increases the DNA-binding affinity and transactivation capacity of c-Myb27,28. Meanwhile, phosphorylation of serine residues 11 and 12 by casein kinase II decreases DNA-binding affinity42, whereas phosphorylation of serine residue 528 in the NRD lowers ...
FIG 12. Deletion of badL lowers the level of pucC RNA transcripts, an effect that is independent of the presence or absence of BadM. Total RNA of cells grown photosynthetically with succinate plus benzoate was harvested as described in Materials and Methods. Expression of pucC was assessed in ...
H. pylori affects the regulation of signaling pathways and lowers the threshold for cellular carcinogenesis through the release of several virulence factors, including cytotoxin-associated gene A (CagA), pathogenicity island (Cag PAI), and vacuolar cytotoxin A (VacA), which are translocated into the...
12. Bacterial GNATs are classified into several different subgroups depending on the presence of additional C- and/or N-terminal domains, which were shown to either interfere with folding of the catalytic domain, to allosterically modulate GNAT catalytic activity upon ligand binding, which affects ...
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells Cancer Res., 63 (2003), pp. 5126-5135 View in ScopusGoogle Scholar Ogiso et al...