Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different gen...
Define acetyl-CoA. acetyl-CoA synonyms, acetyl-CoA pronunciation, acetyl-CoA translation, English dictionary definition of acetyl-CoA. n. See acetyl coenzyme A. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016
Measurement of intracel- lular acetyl-CoA and malonyl-CoA in bacteria and yeasts using acyl-CoA cycling. Agric. Biol. Chem. 52:843-844.Nomura, G., Y. Yoshida and Y. Takamura. 1988. Measurement of intracellular acetyl-CoA and malonyl-CoA in bacteria and yeasts using acyl-CoA cycling. ...
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ...
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes....
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It carboxylates acetyl-CoA to generate malonyl-CoA in a biotin-dependent manner, which is then covalently attached to the multifunctional fatty acid synthase (FAS) to synthesize palmitate, a C16 saturated fatty acid20. Because ACC acts at the top of a major met- abolic pathway, it has ...
Acetyl-CoA and malonyl-CoA measurement 20mg liver tissues were homogenized in 20μL water for 3min, 70μL of mixture containing methanol: chloroform: water (5:2:2) was added and samples are homogenized for 1min (BB24, Next Advance, Inc., NY, USA). After homogenization, the samples were...
(measured as the incorporation of14C into malonyl CoA) was dependent on both pCS11 protein and acetyl CoA substrate. Because this an endpoint assay, it is less suitable than the spectrophotometric assay for kinetic measurements; however, it is superior for detecting activity in crude preparations....
Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals.Describes the biochemical and acute physiological properties of CP-...