Moreau K, Dizin E, Ray H, Luquain C, Lefai E, et al. (2006) BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase . J Biol Chem 281 : 3172–3181Moreau K, Dizin E, Ray H, et al. BRCA1 affects lipid synthesis through its interaction with acetyl-CoA ...
cytosolic and nuclear acetyl-CoA via ACL. Together, cytoplasmic and nuclear acetyl-CoA level is not only regulated by mitochondrial acetyl-CoA level, but also controlled by ACL activity. Through ACL,glucose metabolismof cancer cells is tightly linked to lipid synthesis and histone acetylation (...
or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase....
Acetyl-CoA is indeed the actual molecule through which glycolytic pyruvate enters the tricarboxylic acid (TCA) cycle, is a key precursor of lipid synthesis, and is the sole donor of the acetyl groups for acetylation (Choudhary et al., 2014). Acetyl-CoA is a membrane-impermeant molecule ...
Kang,(1994) The activity of acetyl-CoA carboxylase is not correlated with the rate of lipid synthesis during development of oilseed rape (Brassica trapus L.) embryos. Planta 193: 320-325.Kang, F., Ridout, C.J., Morgan, C.L., Rawsthorne, S. (1994) The activity of acetyl-CoA ...
However, the source of the other is relatively single, mainly derived from acetyl CoA. On the other hand, acetyl CoA has diverse functions, as it participates in various activities such as lipid synthesis and energy metabolism. The other is responsible for fatty acid synthesis and regulating ...
tricarboxylic acid cycle, a key precursor of lipid synthesis, and a donor of the acetyl group for protein and histone acetylation.4 Furthermore, acetyl-CoA participates in the regulation of cell growth and proliferation.5 In aerobic conditions, acetyl-CoA is generated by the conversion of ...
- 《European Journal of Lipid Science & Technology》 被引量: 17发表: 2007年 Rat liver acetoacetyl-CoA synthetase This chapter focuses on rat liver acetoacetyl-CoA synthetase. Acetoacetyl-CoA synthetase is a cytosolic enzyme, which is found in lipogenic tissues of the ... JD Bergstrom,J ...
Here we demonstrated that in BLCA cells, ACSS3 is localized in mitochondria and functions as an oncogene to promote lipid synthesis and histone acetylation through the use of acetate. Importantly, our data showed that the expression level of ACSS3 were significantly upregulated in BLCA cell ...
Cytosolic acetyl-CoA synthetase (AceCS1) activates acetate to supply the cells with acetyl-CoA for lipid synthesis. The cDNA for the mammalian AceCS1 has b... Y Ikeda,J Yamamoto,M Okamura,... - 《Journal of Biological Chemistry》 被引量: 543发表: 2001年 Molecular Characterization of Human...