One frequently reported side effect of chemotherapeutic agents like doxorubicin (Doxo) is impaired cognitive function, commonly known as "chemotherapy-induced cognitive impairment (CICI)", which may mimic accelerated brain aging. The biological mechanisms underlying the adverse effects of Doxo on the ...
In addition, we tested whether associations were limited to overweight individuals, smokers, those on antipsychotic medication whose side effects may mimic signs of accelerated aging,17 and individuals who had already been diagnosed with an age-related disease. Methods Sample Participants were members ...
S. et al. Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? Semin. Oncol. 40, 709–725 (2013). PubMed Google Scholar Cupit-Link, M. C. et al. Biology of premature ageing in survivors of cancer. ESMO Open 2...
Moregrooming, more check-ups, more details to attend to... this is just the way it is with aging: 7. Train Your Mind to See Solutions to Aging Aging for adults has benefits, too. For example, many people in their fifties report experiencing morecalmness of mindthan at any other time ...
(PREVENT-AD cohort), neitherAPOEε4 status nor PET evidence of Aβ pathology was associated with apparent accelerated brain aging but individuals closer to their parental age of onset tended to show accelerated brain aging. Secondary analyses in a third independent cohort including a small subset ...
Recombination of the rDNA locus has been shown to be a major cause of yeast replicative aging (27, 28). We therefore examined the effect of nicotinamide on yeast life span. Cells were grown for 2 days on fresh YPD medium to ensure that they were not calorie restricted prior to the assay...
From a biological point of view, the same trend of accelerated aging has been observed with the use of aging biomarkers [17]. The latest and powerful generations of biomarkers which are based on different approaches have been applied to cohorts of DS adults. Interestingly, these different biomark...
Dr. Stephen Salloway, Director of Neurology and the Memory and Aging Program at Butler Hospital, said, “This approval represents a major advance in the treatment of Alzheimer’s disease. By reducing amyloid beta ...
Aging of schizophrenia patients is associated with reduced longevity, but the potential biological factors associated with aging in this population have not yet been investigated in a global manner. To address this gap in knowledge, the present study assesses proteomics and metabolomics profiles in the...
In obesity, the brain becomes insulin resistant and can have too much glucose, which is associated with accelerated brain aging and may involve NO-induced oxidative damage to neuronal mitochondria [283, 284]. However, both starvation and triglycerides reverse obesity-induced suppression of insulin ...