结论 采用ABVD第1,8天用药方案治疗初治Ⅱ～Ⅳ期HL与第1,15天用药方案治疗CR率,1年DFS率,2年DFS率比较均相似,但A组有优于B组的趋势,治疗相关的毒副反应也相似,但在治疗时间上A组显著缩短.%Objective To explore the effect of adriamycin, bleomyein, vincristine and dacarbazinum (ABVD) chemotherapy ...
Studies evaluating dose intensity in MOPP-based chemotherapy for HL have shown that administering full doses without treatment delays results in improved disease-free and overall survival [24,25]. However, the precise level of dose intensity required to achieve these better outcomes was not clearly ...
UK and 6Department of Medical Oncology, Southampton General Hospital, Southampton, UK Background: Myelotoxicity during initial cycles of chemotherapy for Hodgkin lymphoma is associated with better outcome, supporting the concept of individualised dosing based on pharmacodynamic end points to optimise results...
Antiemetic treatment compliance is important to prevent chemotherapy-induced nausea and vomiting, a feared chemotherapy side effect. NEPA, a new oral fixed... S Calcagnile,C Lanzarotti,M Gutacker,... - 《Clinical Pharmacology in Drug Development》 ...
To improve clinician awareness, we systematically reviewed side effects of chemotherapy for Hodgkin lymphoma (HL) in young males. Methods: The review was prospectively registered (PROSPERO N. CRD42019122868). Three databases (Medline via PUBMED, SCOPUS, and Cochrane Library) were searched for studies...
The mean duration of remission was 100,6 months (m) in CR and 12,4 m in PR. Two patients relapsed from CR. 22 from PR 43 patients died during the observation time. Two patients committed suicide. one patient died because of secondary AML. In 40 cases the cause of death was the ...
Introduction: Granulocyte Colony-Stimulating Factor (G-CSF) is commonly used to maintain dose intensity in patients receiving ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine) for Hodgkin lymphoma. However, the need for growth factor support is unclear, with studies suggesting that ...
Ninety-four patients with HD clinical stages I to III A with no staging laparotomy were treated by three courses of ABVD followed by radiotherapy. Irradiation was performed on extended fields in 41 cases and on involved fields in 53 others. Consolidation chemotherapy was planned in 67 cases with...
doseintensityIntroduction: Granulocyte Colony-Stimulating Factor (G-CSF) is commonly used to maintain dose intensity in patients receiving ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine) for Hodgkin lymphoma. However, the need for growth factor support is unclear, with studies ...