The commonest grade 3-4 acute adverse effects of this regime, based on the Italian GISL study, include neutropenia (34%), alopecia (31%), nausea/vomiting (13%), anemia (5%), thrombocytopenia (3%), infections (2%), constipation (2%), and mucositis (1%) [17]. Long-term toxicities of...
The aim of treatment for advanced stage Hodgkin lymphoma (HL) is to maximise the cure rate, while minimising short- and long- term toxicity (Bauer et al, 2011). ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) is a commonly used drug combination (Cheson, 2007) and although more ...