DLL4 is induced by VEGF and acts to the downstream of VEGF, and synergistic effect for dual blockade of both DLL4 and VEGF was evaluated in preclinical models. A phase 1b study assessed the safety, tolerability, pharmacokinetics and efficacy of CTX-009 in combination with paclitaxel or ...
ABL001/CTX-009 is a bispecific antibody targeting delta-like ligand-4 and vascular endothelial growth factor A. In this study, we developed a population pharmacokinetic (PK) model of ABL001/CTX-009 in patients with solid tumors. A total of 712 plasma concentrations from 30 patient...