Gene expression profiling of CD56, CD117, CD52 and CD20 mRNA in plasma cells (PCs) from patients treated on Total Therapy 2 and Total Therapy 3 trials were also evaluated. Higher expression of CD56 and CD117 was associated with hyperdiploidy. High CD52 mRNA expression was associated with c...
The World Health Organization (WHO) characterization of the immunophenotype of precursor B-cell acute lymphoblastic leukemia (BALL)/ lymphoblastic lymphoma (LBL) includes the possible expression of myeloid cluster of differentiation (CD) markers CDI3 and CD33. In precursor T-cell ALL/LBL, myeloid mar...
Patients with mutated NIK exhibit B-cell lymphopenia, decreased frequencies of class-switched memory B cells and hypogammaglobulinemia due to impaired B-cell survival, and impaired ICOSL expression. Although overall T-cell numbers are normal, both follicular helper and memory T cells are perturbed....
Twenty-nine of the 40 AML cases analyzed (73%) showed the existence of at least one aberrant phenotype: in 15 cases the myeloid blast cells co-expressed lymphoid-associated antigens (CD2, CD5, CD7, and/or CD19)--lineage infidelity--; asynchronous antigen expression was detected in 25 ...
Flow cytometry analysis showed the blasts were positive for CD10, CD19, CD20, CD22, CD45, HLA-DR, TdT, and negative for CD2, CD3, CD5, CD7, CD13, CD14, CD15, CD33, CD34, CD56, CD64, CD71, CD117, myeloperoxidase (MPO), consistent with B-acute lymphoblastic leukemia (B-ALL). ...
(Supplementary Fig. 8). Both CD56brightand CD56dimNK cells, representing subsequent stages of NK cell development, were present (Fig. 7aandSupplementary Fig. 8). In addition, patients expressed markers associated with pre-terminal NK-cell developmental stages, including CD117, CD27, CD11a, KIR...