Microglial phagocytosis and disease-associated microglia (DAM) should play important roles in this process. Additionally, microglia can be activated by various mediators and further propagate neuroinflammation. Abbreviations: NPLE: neuropsychiatric lupus erythematosus; CNS: central nerve system; BBB: blood-...
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed:12626582, PubMed:15331440, PubMed:16258195, PubMed:19122197, PubMed:20103766, PubMed:21325622, PubMed:8423249). It can induce neutrophil chemotaxis,...
NK cells rather kill extracellularly by releasing toxic proteins like perforin and proteases into the immunological synapse (ADCC), whereas macrophages primarily engulf and phagocytose target cells via antibody-dependent cellular phagocytosis (ADCP). It should be noted, that neutrophils and eosinophils ...
As an Fc-enhanced anti-CTLA-4 antibody, BOT also promotes intratumoral Treg depletion via antibody-dependent cellular cytotoxicity and phagocytosis mechanisms. These qualities differentiate BOT from approved CTLA-4 antibodies with the potential for BOT to extend benefit to ‘cold’ or ICB-refractory ...
CD16 is a 50-70-kDa low affinity Fc receptor found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16 mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. CD16 has been iden...
Antibody-dependent cell-mediated cytotoxicity ADCP: Antibody-dependent cellular phagocytosis AE: Adverse event ANC: Absolute neutrophil count CLL: Chronic lymphocytic leukaemia CRUK: Cancer Research UK CTCAE: Common terminology criteria for adverse events DLBCL: Diffuse large B-cell lymphoma DLT...
Tafasitamab (Monjuvi, tafasitamab-cxix) (Table 6.1) is a humanized anti-CD19 antibody with an engineered Fc domain, it works via apoptosis and Fc-dependent mechanisms, including antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cell-mediated cytotoxicity (ADCC) (Horton et al...
4575#Background:Maximizing antibody dependent cellular phagocytosis (ADCP) in the tumor microenvironment requires both the inhibition of the myeloid CD47/SIRP伪 checkpoint and activation of the macrophage's FcyR by an anti-cancer specific antibody (Lakhani et al.Lancet Oncol2021). Evorpacept (EVO)...
Ex Vivo Activation of Neutrophils by CHIPS is Also Dependent on α-Chips IgG Concentration We measured the effect of CHIPS on neutrophil activation in a whole blood ex vivo assay. Since α-CHIPS antibodies are already present in whole blood we did not preincubate CHIPS with affinity purified-α...
As is well documented in the art, the Fc region of an antibody mediates its serum half-life and effector functions, such as complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell phagocytosis (ADCP)....